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Canine Transmissible Venereal Tumor: A Review

机译：犬传染性性腺肿瘤的研究进展

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Canine transmissible venereal tumor (TVT) is a commonly occurring tumor of dogs affecting both sexes. It is common in dogs which have an uncontrolled sexual behavior with incidence ranging from 2 to 43 percent of all tumors in temperate climates. The etiology appears to be cell transplant from affected to unaffected dogs. The pathogenesis, gross and microscopic findings, diagnosis, prognosis and therapies have been reviewed. Gross findings of small nodule like lesions which bleed is the most consistent clinical finding. Smears made from the tumor reveal round cells with vacuoles and mitotic figures. The tumor is many times self limiting and vincristine sulfate is currently considered the most effective therapy. The use of vincristine sulfate in male dogs must balance the potential benefits to the patient and the interest in using the animal for breeding as vincristine sulfate impairs the semen quality. Immune therapy of TVT is still to be validated for clinical use.
机译：犬可传播的性病（TVT）是影响男女的狗的常见肿瘤。它在性行为不受控制的狗中很常见，在温带气候下，其发生率占所有肿瘤的2％至43％。病因似乎是从患病犬到未患病犬的细胞移植。对其发病机理，总体和微观发现，诊断，预后和治疗方法进行了综述。最一致的临床发现是小结节样病变出血的总体发现。由肿瘤制成的涂片显示圆形细胞带有液泡和有丝分裂的图形。肿瘤多次自我限制，硫酸长春新碱目前被认为是最有效的治疗方法。在雄性犬中使用硫酸长春新碱必须平衡对患者的潜在益处，并且由于硫酸长春新碱会损害精液质量，因此在使用动物进行繁殖的兴趣上也要取得平衡。 TVT的免疫疗法仍有待临床验证。

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