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首页> 外文期刊>Turkish Journal of Veterinary and Animal Sciences >Assessment of tumor-induced pain and C-reactive protein levels in dogs with canine transmissible venereal tumors
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Assessment of tumor-induced pain and C-reactive protein levels in dogs with canine transmissible venereal tumors

机译：评估犬可传播性病的犬的肿瘤引起的疼痛和C反应蛋白水平

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The aim of this study was to determine the impact of tumor volume on generalized behavior, pain perception, and serum C-reactive protein (CRP) in dogs with canine transmissible venereal tumors (CTVTs). Pain scoring was performed using the Glasgow Composite Measure Pain Scale Short-Form. Cytomorphology of the tumors was studied through fine-needle aspiration and histopathology. Molecular identification of CTVTs was carried out using PCR assays based on LINE-1/ c-myc . Hematological profiles including complete blood count and CRP were analyzed using an automatic hematology analyzer and immunoturbidimetric assays, respectively. Chi-square and regression analysis statistics were used for data analysis. Results of the study revealed a statistically significant (R$^{2}$ = 0.798) impact of tumor volume on pain scores in corresponding individuals. Hematological parameters and serum CRP values were observed in normal ranges and did not reveal any significant association with tumor volume. All of the samples were found positive for LINE-1/ c-myc molecular rearrangement, revealing a 552-bp PCR product. On the basis of cytology tumors were differentiated into plasmacytoid, lymphocytoid, and mixed types. No significant association could be observed among cytological types and sex of the individuals. It may be concluded that increasing tumor size may result in localized pain and mild behavioral alterations in affected dogs. However, hematology profiles and serum CRP levels are independent of the localized tumor proliferation.
机译：这项研究的目的是确定肿瘤体积对犬可传播性病（CTVT）犬的行为，疼痛知觉和血清C反应蛋白（CRP）的影响。使用Glasgow Composite Measure Pain Scale Short-Form进行疼痛评分。通过细针穿刺和组织病理学研究了肿瘤的细胞形态。使用基于LINE-1 / c-myc的PCR分析法对CTVT进行分子鉴定。分别使用自动血液分析仪和免疫比浊法分析了包括全血细胞计数和CRP在内的血液学特征。卡方和回归分析统计数据用于数据分析。研究结果显示，肿瘤体积对相应个体的疼痛评分有统计学意义（R $ ^ {2} $ = 0.798）的影响。在正常范围内观察到血液学参数和血清CRP值，未发现与肿瘤体积有任何显着相关性。发现所有样品均对LINE-1 / c-myc分子重排呈阳性，揭示了552-bp PCR产物。在细胞学的基础上，将肿瘤分为浆细胞样，淋巴细胞样和混合型。在个体的细胞学类型和性别之间未观察到明显的关联。可以得出结论，增加肿瘤的大小可能会导致患犬局部疼痛和轻度的行为改变。但是，血液学特征和血清CRP水平与肿瘤的局部增殖无关。

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