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首页> 外文期刊>The Journal of Veterinary Medical Science >Poorly differentiated salivary gland carcinoma with prominent squamous metaplasia in a pregnant Wistar Hannover rat
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Poorly differentiated salivary gland carcinoma with prominent squamous metaplasia in a pregnant Wistar Hannover rat

机译：Wistar汉诺威（Wanstar）怀胎大鼠分化不良的唾液腺癌及鳞状上皮化生

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References(17) A subcutaneous pale brown-colored mass was observed macroscopically in the ventral neck of a 16-week-old Wistar rat on day 18 of gestation. The mass was well demarcated from the adjacent tissues with partial invasion into connective tissues. Necrosis and hemorrhage were evident throughout the mass. The mass comprised a diffuse sheet and a nest-like structure of epithelial cells with prominent squamous metaplasia. The neoplastic cells tested immunopositive for keratin, vimentin, glial fibrillary acidic protein and p63. A portion of the neoplastic cells exhibited a similar immunoreaction of prominin-1 to the ductal and acinar cells in normal submandibular and parotid glands. Collectively, the tumor was diagnosed as a poorly differentiated carcinoma derived from epithelial/myoepithelial lineages in the submandibular and/or parotid glands.
机译：参考文献（17）在妊娠第18天，在一只16周大的Wistar大鼠的腹侧颈部肉眼观察到了皮下的浅棕色肿块。肿块从邻近组织中很好地分界，部分浸润到结缔组织中。整个肿块均可见坏死和出血。肿块由上皮细胞弥漫性片状和巢状结构组成，鳞状上皮化生。肿瘤细胞对角蛋白，波形蛋白，神经胶质纤维酸性蛋白和p63呈免疫阳性。在正常的颌下腺和腮腺中，部分肿瘤细胞表现出prominin-1对导管和腺泡细胞的类似免疫反应。集体地，该肿瘤被诊断为来自下颌下和/或腮腺中的上皮/肌上皮谱系的低分化癌。

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