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首页> 外文期刊>Diagnostic cytopathology >Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation.
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Salivary duct carcinoma cytologically diagnosed distinctly from salivary gland carcinomas with squamous differentiation.

机译：细胞学上诊断与涎腺癌鳞状细胞分化明显区别的唾液管癌。

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摘要

It has been difficult cytologically to distinguish salivary duct carcinoma (SDC) from high-grade carcinoma. We investigated the microscopic cytological findings, morphometric image analyses, and immunohistochemical features of SDC, focusing on how we achieved an accurate differential diagnosis distinguishing SDC from salivary gland carcinomas with squamous differentiation. Immunohistochemical staining was performed for androgen receptor (AR), gross cystic disease fluid protein-15 (GCDFP15), mammaglobin, human gastric mucin, MUC1, MUC2, p63, and cytokeratin high molecular weight. Of the 13 cases of SDC, 9 cases showed typical cytological findings of sheet clusters with polygonal granular cytoplasm with fine chromatin. The other 4 cases showed unusual cytological findings of a pseudo-papillary cluster or scattered cells only, and the tumor cells showed coarse chromatin. Morphometric image analysis showed that the nucleus area was statistically different between SDC and salivary gland carcinomas with squamous differentiation. AR-positive expression (P = 0.008), GCDFP15-positive expression (P = 0.005) and p63-negative expression (P = 0.001) were effective as SDC-specific markers in immunohistochemistry. An accurate cytological diagnosis of SDC can be determined by immunostaining with AR, GCDFP15, and p63, based on the nuclear findings.
机译：细胞学上很难区分涎腺导管癌（SDC）和高级别癌。我们调查了SDC的微观细胞学发现，形态图像分析和免疫组化特征，重点研究了如何实现将SDC与具有鳞状分化的唾液腺癌区分开的准确的鉴别诊断。对雄激素受体（AR），总囊性疾病液蛋白15（GCDFP15），乳球蛋白，人胃粘蛋白，MUC1，MUC2，p63和细胞角蛋白高分子量进行了免疫组织化学染色。在SDC的13例病例中，有9例表现出典型的片状簇细胞学表现，片状簇具有多边形颗粒细胞质且染色质良好。其他4例仅显示假乳头状簇或散在细胞的异常细胞学表现，肿瘤细胞染色质较粗糙。形态图像分析显示，SDC和唾液腺癌的鳞状分化之间的核面积有统计学差异。在免疫组织化学中，AR阳性表达（P = 0.008），GCDFP15阳性表达（P = 0.005）和p63阴性表达（P = 0.001）有效作为SDC特异性标记。可以基于核发现，通过用AR，GCDFP15和p63进行免疫染色来确定SDC的准确细胞学诊断。

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