Primaquine Administration after Falciparum Malaria Treatment in Malaria Hypoendemic Areas with High Incidence of Falciparum and Vivax Mixed Infection: Pros and Cons

Wilairatana Polrat; Tangpukdee Noppadon; Kano Shigeyuki; Krudsood Srivicha

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Primaquine Administration after Falciparum Malaria Treatment in Malaria Hypoendemic Areas with High Incidence of Falciparum and Vivax Mixed Infection: Pros and Cons

机译：恶性疟低流行区恶性疟和Vivax混合感染高发地区的恶性疟疾治疗后的伯氨喹管理：利弊

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Mixed infections of Plasmodium falciparum and Plasmodium vivax is high (~30%) in some malaria hypoendemic areas where the patients present with P. falciparum malaria diagnosed by microscopy. Conventional treatment of P. falciparum with concurrent chloroquine and 14 days of primaquine for all falciparum malaria patients may be useful in areas where mixed falciparum and vivax infections are high and common and also with mild or moderate G6PD deficiency in the population even with or without subpatent vivax mixed infection. It will be possibly cost-effective to reduce subsequent vivax illness if the patients have mixed vivax infection. Further study to prove this hypothesis may be warranted.

机译：在一些疟疾低流行区，恶性疟原虫和间日疟原虫的混合感染率很高（〜30％），在显微镜检查下，这些患者表现出恶性疟原虫的存在。对于所有恶性疟疾患者，常规的恶性疟原虫同时用氯喹和伯氨喹联合治疗14天，对于恶性疟和间质混合感染高发和常见，以及即使有或没有亚专利的人群，其轻度或中度G6PD缺乏症也可能有用间质混合感染。如果患者患有混合型天疱疮感染，减少随后的天疱疮疾病可能是具有成本效益的。可能需要进行进一步的研究以证明这一假设。

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《The Korean Journal of Parasitology》 |2010年第2期|共3页
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Wilairatana Polrat; Tangpukdee Noppadon; Kano Shigeyuki; Krudsood Srivicha;
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1. Primaquine Administration after Falciparum Malaria Treatment in Malaria Hypoendemic Areas with High Incidence of Falciparum and Vivax Mixed Infection: Pros and Cons [J] . Wilairatana Polrat, Tangpukdee Noppadon, Kano Shigeyuki, The Korean Journal of Parasitology . 2010,第2期

机译：恶性疟疾低发区，恶性疟原虫和Vivax混合感染高发地区的恶性疟疾治疗后的伯氨喹管理：利弊
2. Clustered local transmission and asymptomatic Plasmodium falciparum and Plasmodium vivax malaria infections in a recently emerged, hypoendemic Peruvian Amazon community [J] . OraLee Branch, W Martin Casapia, Dionicia V Gamboa, Malaria Journal . 2005,第S1期

机译：在最近出现的低流行性秘鲁亚马逊社区中，聚集了局部传播和无症状的恶性疟原虫和间日疟原虫疟疾感染
3. Randomised placebo-controlled trial of primaquine for prophylaxis of falciparum and vivax malaria. [J] . et al. The Lancet . 1995,第8984期

机译：伯氨喹预防恶性疟和间日疟的随机安慰剂对照试验。
4. Impact of climate variability on Plasmodiurn vivax and Plasmodium falciparum malaria in the high risk area of Yunnan Province, China [C] . Yan Bi, Weiwei Yu, Wenbiao Hu, Annual conference of the International Society of Exposure Science . 2014

机译：气候变化对云南省高危地区间日疟原虫和恶性疟原虫疟疾的影响
5. Whole Genome Analysis of the Human Malaria Parasites Plasmodium vivax and P. falciparum. [D] . Bright, Andrew Taylor. 2013

机译：人类疟原虫间日疟原虫和恶性疟原虫的全基因组分析。
6. Primaquine Administration after Falciparum Malaria Treatment in Malaria Hypoendemic Areas with High Incidence of Falciparum and Vivax Mixed Infection: Pros and Cons [O] . Polrat Wilairatana, Noppadon Tangpukdee, Shigeyuki Kano, 2010

机译：恶性疟低流行区恶性疟和Vivax混合感染高发地区的恶性疟疾治疗后给予伯氨喹：利弊
7. Primaquine Administration after Falciparum Malaria Treatment in Malaria Hypoendemic Areas with High Incidence of Falciparum and Vivax Mixed Infection: Pros and Cons [O] . Wilairatana, Polrat, Tangpukdee, Noppadon, Kano, Shigeyuki, 2010

机译：恶性疟低流行区恶性疟和Vivax混合感染高发地区的恶性疟疾治疗后给予伯氨喹：利弊

Primaquine Administration after Falciparum Malaria Treatment in Malaria Hypoendemic Areas with High Incidence of Falciparum and Vivax Mixed Infection: Pros and Cons

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