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首页> 外文期刊>The Korean Journal of Parasitology >Lymphadenitis in experimental murine toxoplasmosis induced by intramuscular injection of tachyzoites
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Lymphadenitis in experimental murine toxoplasmosis induced by intramuscular injection of tachyzoites

机译：肌内注射速殖子引起的实验性弓形虫病的淋巴结炎

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When tachyzoites (RH strain) of Toxoplasma gondii are injected intramuscularly, experimental mice survive up to 7 days, 1-2 days longer than those infected intraperitoneally. We observed sequential histopathological changes in inguinal lymph nodes after intramuscular injection of tachyzoites to thighs of specific pathogen free (SPF) mice. Initial findings on 1 or 3 days after the injection were reactive germinal centers, distended sinuses and epithelioid cell clusters in cortical and paracortical regions. Later on 5 days after the injection, however, effacement of nodal structure with depletion of cells and focal necrosis were observed. Necrotizing lymphadenitis in the experimental murine toxoplasmosis suggests the causal relation between T. gondii infection and the human disease.
机译：肌肉注射弓形虫的速殖子（RH株）时，实验小鼠的存活时间长达7天，比腹膜内感染的小鼠长1-2天。我们观察到腹股沟淋巴结在肌肉注射速殖子到特定的无病原体（SPF）小鼠大腿后的连续组织病理学变化。注射后1或3天的最初发现是皮层和皮层旁区域的反应性生发中心，鼻窦扩张和上皮样细胞团。然而，注射后5天，观察到淋巴结结构消失，细胞耗尽和局灶性坏死。实验性鼠弓形虫病中的坏死性淋巴结炎表明弓形虫感染与人类疾病之间存在因果关系。

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