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The vaccine composition against toxoplasmosis and caseous lymphadenitis using recombinant Corynebacterium pseudotuberculosis

机译：用重组假结核杆菌预防弓形虫和干酪性淋巴结炎的疫苗组合物

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摘要

Composiqao vaccine against toxoplasmosis and caseous lymphadenitis using recombinant Corynebacterium pseudotuberculosis this invengao consists of a composigu00e9o recombinant vaccine with activity profilatica to infecgoes for Toxoplasma gondii and Corynebacterium pseudotuberculosis, concomita Ntemente, in animals, preferably, goats and sheep. Based on the employment of C.Pseudotuberculosis attenuated recombinant capable of expressing immunogenic proteins in response Antitoxoplasma encoded by sequu00e9ncias modified (SEQ ID NO 1) SAG1 SAG2 (SEQ ID No. 2, SAG3 (SEQ ID) and (3). This invengao has the advantage of reducing the loss production in herds, as well as to reduce the risk of transmission of toxoplasmosis to human consumers.Su00e9o inegaveis also the advantages econu00e9micas vaccines able to immunize against more than _ a doenga on monovalent vaccines, both in the context of industrial produgao as part of a protocol clnico of imunizagao. The technology also relates to recombinant bacteria produced, which was able to express the proteins of T.Gondii correctly and to stimulate humoral immune response in mice immunized with this vector, as well as the use of composigao and bacteria in this activity profilatica, as well as the plasmideos constructed and incorporated into the bacteria.

机译：本发明由弓形虫和伪结核杆菌组成的针对弓形虫和干酪样淋巴结炎的组合疫苗，由一种具有活性的弓形虫复合疫苗组成，该弓形虫可以感染弓形虫和弓形棒杆菌，同时在动物中，最好是山羊和绵羊。基于假单胞菌的减毒重组，能够表达免疫原性蛋白质，以响应由序列修饰的（SEQ ID NO 1）SAG1 SAG2（SEQ ID No. 2，SAG3（SEQ ID）和（3）编码的抗弓形虫。 invengao的优势在于减少了牛群的生产损失，并降低了弓形虫病向人类消费者传播的风险。inegaveis的优势还在于econmica疫苗能够针对单价疫苗的多点免疫力，在工业生产过程中作为imunizagao协议的一部分，该技术还涉及产生的重组细菌，该细菌能够正确表达T.Gondii的蛋白质，并能激发用该载体免疫的小鼠的体液免疫应答，以及在这种活性分布图中使用组合物和细菌，以及构建并掺入细菌的质粒。

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公开/公告号BR102013019138A2

专利类型
公开/公告日2016-09-20

原文格式PDF
申请/专利权人 UNIVERSIDADE FEDERAL DE MINAS GERAIS;
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申请/专利号BR20131019138
发明设计人 VASCO ARISTON DE CARVALHO AZEVEDO;FERNANDA ALVES DORELLA;MARA CAMILA ARANTES MARQUES DE AGUIAR;OSCAR BRUÑA ROMERO;
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申请日2013-07-26
分类号A61K39/012;A61P31/04;A61P33/02;C07K14/45;C12N1/21;C12N15/30;
国家 BR
入库时间 2022-08-21 14:27:21

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