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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Acute Toxicity and General Pharmacological Action of QGC EXT
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Acute Toxicity and General Pharmacological Action of QGC EXT

机译：QGC EXT的急性毒性和一般药理作用

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It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute toxicity and the general pharmacological action of QGC EXT to search for any side effects of it in rats, mice, guinea pigs, and cats. In a single dose toxicity study, QGC EXT didn't show toxicological effects in rats and mice, and the LD50 was over 5 g/kg in both animals, and there were also no changes in weight, feed and water intake during these toxicological experimental periods. We examined the general pharmacological action on central controlled behavior responses, and peripheral organs including blood pressure, heart rate, respiration and gastrointestinal system, We found that there were no significant changes in body temperature, locomotors activity, stereotyped behaviors, sleeping time, and convulsion. In other studies, writhing reaction, normal body temperature, there did not appear to be any changes. The large intestine movement and electrical field stimulation-induced contraction was not changes by its EXT. In addition, the influences on blood pressure, heart rates, and respiration by QGC EXT were not found. These results indicate that QGC EXT may be very safe as a new drug, since its LD50 was very high over 5 g/kg and any side effects were not found.
机译：已经显示，从芸苔叶中分离和纯化的QGC具有胃炎和食道炎的保护作用，其中EXT是其的乙醇提取物。我们检查了QGC EXT的急性毒性和一般药理作用，以寻找它在大鼠，小鼠，豚鼠和猫中的任何副作用。在单剂量毒性研究中，QGC EXT对大鼠和小鼠均未显示出毒理作用，并且两只动物的LD 50 均超过5 g / kg，并且体重也没有变化，在这些毒理学实验期间的饲料和水摄入量。我们检查了对中枢控制行为反应以及包括血压，心率，呼吸和胃肠系统在内的周围器官的一般药理作用。我们发现体温，运动能力，刻板行为，睡眠时间和抽搐没有明显变化。在其他研究中，扭体反应，正常体温似乎没有任何变化。大肠运动和电场刺激引起的收缩没有被其EXT改变。此外，未发现QGC EXT对血压，心率和呼吸的影响。这些结果表明，QGC EXT作为一种新药可能非常安全，因为其LD 50 超过5 g / kg时非常高，并且未发现任何副作用。

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