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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Improvement Characteristics of Bio-active Materials Coated Fabric on Rat Muscular Mitochondria
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Improvement Characteristics of Bio-active Materials Coated Fabric on Rat Muscular Mitochondria

机译：生物活性材料包覆织物对大鼠肌肉线粒体的改善特性

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This study surveys the improvement characteristics in old-aged muscular mitochondria by bio-active materials coated fabric (BMCF). To observe the effects, the fabric (10 and 30%) was worn to old-aged rat then the oxygen consumption efficiency and copy numbers of mitochondria, and mRNA expression of apoptosis- and mitophagy-related genes were verified. By wearing the BMCF, the oxidative respiration significantly increased when using the 30% materials coated fabric. The mitochondrial DNA copy number significantly decreased and subsequently recovered in a dose-dependent manner. The respiratory control ratio to mitochondrial DNA copy number showed a dose-dependent increment. As times passed, Bax, caspase 9, PGC-1α and β-actin increased, and Bcl-2 decreased in a dose-dependent manner. However, the BMCF can be seen to have had no effect on Fas receptor. PINK1 expression did not change considerably and was inclined to decrease in control group, but the expression was down-regulated then subsequently increased with the use of the BMCF in a dose-dependent manner. Caspase 3 increased and subsequently decreased in a dose-dependent manner. These results suggest that the BMCF invigorates mitophagy and improves mitochondrial oxidative respiration in skeletal muscle, and in early stage of apoptosis induced by the BMCF is not related to extrinsic death-receptor mediated but mitochondria-mediated signaling pathway.
机译：这项研究调查了生物活性物质涂层织物（BMCF）对老年人肌肉线粒体的改善特性。为观察效果，​​将织物（10％和30％）穿在老年大鼠上，然后耗氧效率和线粒体的拷贝数，并验证了凋亡相关基因和线粒体相关基因的mRNA表达。通过使用BMCF，当使用30％材料涂层的织物时，氧化呼吸显着增加。线粒体DNA的拷贝数明显减少，随后以剂量依赖性方式恢复。呼吸控制率与线粒体DNA拷贝数之间呈剂量依赖性。随着时间的流逝，Bax，caspase 9，PGC-1α和β-肌动蛋白增加，而Bcl-2以剂量依赖的方式减少。然而，可以看出BMCF对Fas受体没有作用。 PINK1表达在对照组中没有明显改变并且倾向于降低，但是该表达被下调然后随后以剂量依赖的方式通过使用BMCF而增加。半胱天冬酶3以剂量依赖性方式增加然后减少。这些结果表明，BMCF增强了骨骼肌的线粒体吞噬能力，​​并改善了线粒体的氧化呼吸作用，并且在BMCF诱导的细胞凋亡的早期阶段，它与外部死亡受体介导的无关，而与线粒体介导的信号通路相关。

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