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首页> 外文期刊>The Journal of the South African Veterinary Association >The effects of firocoxib (Previcox?) in geriatric dogs over a period of 90 days
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The effects of firocoxib (Previcox?) in geriatric dogs over a period of 90 days

机译：在90天的时间里，frococibib（Previcox？）对老年犬的影响

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The long-term use of non-steroidal anti-inflammatory agents in geriatric dogs with osteoarthritis has not been well studied in veterinary medicine. This study evaluated the effects of firocoxib administered to dogs over 7 years of age for 90 days. Pain and lameness scores were evaluated by the owner weekly for the 1st month and then biweekly through to the end of the study, the veterinarian evaluated the dogs monthly. Serum chemistry, including urea, creatinine, alanine transferase, aspartate transaminase, bile acids and bilirubin, urine specific gravity and a urine dipstick, were performed at monthly intervals. Forty-five dogs were enrolled into the treatment group and 9 into the control group. A total of 33 dogs completed the trial in the treatment group and 8 in the control group. Lameness and pain scores were found to be significantly lower in the treated group from day 30 for most parameters evaluated. Bile acids (although not comparable to controls, with higher mean value and a high standard deviation in the control group; in addition the control group had increased bile acids at day 0) and urea (within normal reference range provided (WNL)) were significantly different in the treatment group between days 0 and 90. Urea (WNL) on days 30 and 90 and creatinine (WNL) on day 90 were significantly different between the control group and the treatment group. The most common adverse events reported were diarrhoea, vomition, dark faeces and anorexia. This study showed that firocoxib was effective in managing pain associated with osteoarthritis for 90 days. Despite the geriatric high-risk population used for this study, minimal biochemical changes were seen and adverse drug events seen were in agreement with those previously reported.
机译：尚未在兽医领域对在患有骨关节炎的老年狗中长期使用非甾体类抗炎药进行研究。这项研究评估了7岁以上的狗服用90天的rococoxib的效果。主人在第一个月每周评估一次疼痛和la行评分，然后每两周一次直到研究结束，兽医对狗进行每月评估。每月进行一次血清化学检查，包括尿素，肌酐，丙氨酸转移酶，天冬氨酸转氨酶，胆汁酸和胆红素，尿比重和尿量尺。将四十五只狗纳入治疗组，将九只狗纳入对照组。在治疗组中共有33只狗完成了试验，在对照组中有8只狗完成了试验。从第30天开始，对于大多数评估的参数，发现治疗组的行和疼痛评分明显较低。胆汁酸（尽管不能与对照组相比，但对照组具有较高的平均值和较高的标准偏差;此外，对照组在第0天时胆汁酸增加）和尿素（在正常参考范围内（WNL））治疗组在第0天和第90天之间存在差异。第30天和第90天的尿素（WNL）和第90天的肌酐（WNL）在对照组和治疗组之间有显着差异。报告的最常见不良事件为腹泻，呕吐，深色粪便和厌食。这项研究表明，非洛昔布可有效治疗90天内与骨关节炎相关的疼痛。尽管这项研究使用的是老年高危人群，但仍观察到最小的生化变化，并且看到的不良药物事件与先前报道的一致。

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