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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Effects of TGF-β1 Ribbon Antisense on CCl4-induced Liver Fibrosis
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Effects of TGF-β1 Ribbon Antisense on CCl4-induced Liver Fibrosis

机译：TGF-β1条带反义对CCl4诱导的肝纤维化的影响

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摘要

Ribbon-type antisense oligonucleotide to TGF-β1 (TGF-β1 RiAS) was designed and tested to prevent or resolve the fibrotic changes induced by CCl4 injection. When Hepa1c1c7 cells were transfected with TGF-β1 RiAS, the level of TGF-β1 mRNA was effectively reduced. TGF-β1 RiAS, mismatched RiAS, and normal saline were each injected to mice via tail veins. When examined for the biochemical effects on the liver, TGF-β1 mRNA levels were significantly reduced only in the TGF-β1 RiAS-treated group. The results of immunohistochemical studies showed that TGF-β1 RiAS prevented the accumulation of collagen and α-smooth muscle actin, but could not resolve established fibrosis. These results indicate that ribbon antisense to TGF-β1 with efficient uptake can effectively prevent fibrosis of the liver.
机译：设计并测试了针对TGF-β1的带状反义寡核苷酸（TGF-β1RiAS），以预防或解决CCl4注射引起的纤维化变化。用TGF-β1RiAS转染Hepa1c1c7细胞后，TGF-β1mRNA的水平得以有效降低。 TGF-β1RiAS，错配的RiAS和生理盐水分别通过尾静脉注射给小鼠。当检查对肝脏的生化作用时，仅在TGF-β1RiAS治疗组中TGF-β1mRNA水平显着降低。免疫组织化学研究结果表明，TGF-β1RiAS阻止胶原蛋白和α-平滑肌肌动蛋白的积累，但不能解决已建立的纤维化。这些结果表明，通过有效摄取而对TGF-β1反义的带可以有效地预防肝纤维化。

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