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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Spinal Metabotropic Glutamate Receptors (mGluRs) are Involved in the Melittin-induced Nociception in Rats
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Spinal Metabotropic Glutamate Receptors (mGluRs) are Involved in the Melittin-induced Nociception in Rats

机译：脊髓代谢型谷氨酸受体（mGluRs）参与大鼠褪黑素诱导的伤害感受。

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Intraplantar injection of melittin has been known to induce sustained decrease of mechanical threshold and increase of spontaneous flinchings. The present study was undertaken to investigate how the melittin-induced nociceptive responses were modulated by changes of metabotropic glutamate receptor (mGluR) activity. Changes in paw withdrawal threshold (PWT), number of flinchings and paw thickness were measured at a given time point after injection of melittin (10 μg/paw) into the mid-plantar area of rat hindpaw. To observe the effects of mGluRs on the melittin-induced nociceptions, group I mGluR (AIDA, 100 μg and 200 μg), mGluR1 (LY367385, 50 μg and 100 μg) and mGluR5 (MPEP, 200 μg and 300 μg) antagonists, group II (APDC, 100 μg and 200 μg) and III (L-SOP, 100 μg and 200 μg) agonists were intrathecally administered 20 min before melittin injection. Intraplantar injection of melittin induced a sustained decrease of mechanical threshold, spontaneous flinchings and edema. The effects of melittin to reduce mechanical threshold and to induce spontaneous flinchings were significantly suppressed following intrathecal pre-administration of group I mGluR, mGluR1 and mGluR5 antagonists, group II and III mGluR agonists. Group I mGluR antagonists and group II and III mGluR agonists had no significant effect on melittin-induced edema. These experimental findings indicate that multiple spinal mGluRs are involved in the modulation of melittin-induced nociceptive responses.
机译：已知蜂鸣器的足底内注射引起机械阈值的持续降低和自发性退缩的增加。进行本研究以调查蜂毒素诱导的伤害感受反应如何通过代谢型谷氨酸受体（mGluR）活性的变化来调节。在将蜂毒肽（10μg/爪）注入大鼠后足中部区域后的给定时间点，测量爪退缩阈值（PWT），缩颈次数和爪厚度的变化。为了观察mGluRs对蜂毒素诱导的伤害感受的影响，I组mGluR（AIDA，100μg和200μg），mGluR 1 （LY367385、50μg和100μg）和mGluR 5 （MPEP，200μg和300μg）拮抗剂，II组（APDC，100μg和200μg）和III（L-SOP，100μg和200μg）拮抗剂在蜂毒肽注射前20分钟鞘内给药。蜂鸣器的足底内注射引起机械阈值，自发性退缩和水肿的持续降低。在鞘内预先施用I组mGluR，mGluR 1 和mGluR 5 拮抗剂，II组和二肽后，蜂毒肽降低机械阈值和诱导自发性退缩的作用被显着抑制。 III mGluR激动剂。 I组mGluR拮抗剂以及II组和III组mGluR激动剂对蜂毒肽诱导的水肿无明显影响。这些实验结果表明，多种脊髓mGluR参与了蜂毒肽诱导的伤害反应的调节。

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