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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Heat Acclimatization in Hot Summer for Ten Weeks Suppress the Sensitivity of Sweating in Response to Iontophoretically-administered Acetylcholine
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Heat Acclimatization in Hot Summer for Ten Weeks Suppress the Sensitivity of Sweating in Response to Iontophoretically-administered Acetylcholine

机译：在炎热的夏季进行了十周的热适应，抑制了对离子电渗疗法给予乙酰胆碱的出汗敏感性。

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To determine the peripheral mechanisms involved in thermal sweating during the hot summers in July before acclimatization and after acclimatization in September, we evaluated the sweating response of healthy subjects (n=10) to acetylcholine (ACh), a primary neurotransmitter involved in peripheral sudomotor sensitivity. The quantitative sudomotor axon reflex test (QSART) measures sympathetic C fiber function after iontophoresed ACh evokes a measurable reliable sweat response. The QSART, at 2 mA for 5 min with 10% ACh, was applied to determine the directly activated (DIR) and axon reflex-mediated (AXR) sweating responses during ACh iontophoresis. The AXR sweat onset-time by the axon reflex was 1.50±0.32 min and 1.84±0.46 min before acclimatization in July and after acclimatization in September, respectively (p2 and 0.98±0.24 mg/cm2 before acclimatization in July and after acclimatization in September, respectively (p2 and 1.39±0.32 mg/cm2 before and after acclimatization in July and September, respectively (p2 and 4.98±0.94 mg/cm2 before and after acclimatization in July and September, respectively (p
机译：为了确定在适应前的七月炎热的夏天和九月适应后的高温出汗的周围机制，我们评估了健康受试者（n = 10）对乙酰胆碱（ACh）的出汗反应，乙酰胆碱（ACh）是参与周围性运动敏感性的主要神经递质。在离子电渗入的乙酰胆碱引起可测量的可靠汗液反应后，定量sudomotor轴突反射试验（QSART）可测量交感C纤维功能。使用2％mA和5％ACh于2 mA下进行QSART，以确定ACh离子电渗疗法期间直接激活（DIR）和轴突反射介导（AXR）出汗反应。轴突反射引起的AXR出汗时间分别为：7月适应前为1.50±0.32 min，9月适应后为1.84±0.46 min（p2 和0.98±0.24 mg / cm 2 分别在7月和9月的适应前后（p2 和1.39±0.32 mg / cm 2 在7月和9月的适应前后（p2 在7月和9月的适应前后分别为4.98±0.94 mg / cm 2 和（p

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