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首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Relaxant Effect of Spermidine on Acethylcholine and High K+-induced Gastric Contractions of Guinea-Pig
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Relaxant Effect of Spermidine on Acethylcholine and High K+-induced Gastric Contractions of Guinea-Pig

机译：亚精胺对豚鼠乙胆碱和高K +诱导的胃收缩的放松作用

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In our previous study, we found that spermine and putrescine inhibited spontaneous and acetylcholine (ACh)-induced contractions of guinea-pig stomach via inhibition of L-type voltage-dependent calcium current (VDCCL). In this study, we also studied the effect of spermidine on mechanical contractions and calcium channel current ( I Ba), and then compared its effects to those by spermine and putrescine. Spermidine inhibited spontaneous contraction of the gastric smooth muscle in a concentration-dependent manner (IC50=1.1±0.11 mM). Relationship between inhibition of contraction and calcium current by spermidine was studied using 50 mM high K+-induced contraction: Spermidine (5 mM) significantly reduced high K+ (50 mM)-induced contraction to 37±4.7% of the control (pBa was also observed at a wide range of test potential in current/voltage ( I/V ) relationship. Pre- and post-application of spermidine (5 mM) also significantly inhibited carbachol (CCh) and ACh-induced initial and phasic contractions. Finally, caffeine (10 mM)-induced contraction which is activated by Ca2+-induced Ca2+ release (CICR),' was also inhibited by pretreatment of spermidine (5 mM). These findings suggest that spermidine inhibits spontaneous and CCh-induced contraction via inhibition of VDCCL and Ca2+ releasing mechanism in guinea-pig stomach.
机译：在先前的研究中，我们发现精胺和腐胺通过抑制L型电压依赖性钙电流（VDCC L ）抑制豚鼠胃自发性和乙酰胆碱（ACh）引起的收缩。在这项研究中，我们还研究了亚精胺对机械收缩和钙通道电流（I Ba ）的作用，然后将其与精胺和腐胺的作用进行了比较。亚精胺以浓度依赖的方式抑制胃平滑肌的自发收缩（IC 50 = 1.1±0.11 mM）。使用50 mM高K + 诱导的收缩研究了亚精胺抑制收缩与钙电流之间的关系：亚精胺（5 mM）显着降低了高K + （50 mM）在电流/电压（I / V）关系的广泛测试电势下，还观察到诱导收缩至对照（pBa ）的37±4.7％。亚精胺的前后施用（5 mM）还可以显着抑制卡巴胆碱（CCh）和ACh诱导的初始和阶段性收缩;最后，咖啡因（10 mM）诱导的收缩被Ca 2 + 诱导的Ca 2+激活。预处理（5 mM）也抑制了“ sup>释放（CICR）”。这些发现表明，亚精胺通过抑制VDCC L 和Ca 2抑制自发性和CCh诱导的收缩。豚鼠胃中的+ 释放机制。

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