• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Assessment of Relationship between Fyn-related Kinase Gene Polymorphisms and Overweight/Obesity in Korean Population
【24h】

Assessment of Relationship between Fyn-related Kinase Gene Polymorphisms and Overweight/Obesity in Korean Population

机译：Fyn相关激酶基因多态性与韩国人群超重/肥胖之间关系的评估

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The fyn-related kinase (FRK) belongs to the tyrosine kinase family of protein kinases. Recent studies have shown that Frk affects pancreatic beta cell number during embryogenesis and promotes beta cell cytotoxic signals in response to streptozotocin. To investigate the genetic association between FRK polymorphisms and the risk of obesity in Korean population, single nucleotide polymorphisms (SNPs) in the FRK gene region were selected and analyzed. The body mass index (BMI) was calculated, and biochemical data (systolic blood pressure, diastolic blood pressure, hemoglobin A1C, triglyceride, total cholesterol, high density lipoprotein, and low density lipoprotein) of blood sample from each subject were also measured. One hundred fifty five healthy control and 204 overweight/obesity subjects were recruited. Genotype frequencies of six SNPs [rs6568920 (+8391G>A), rs3756772 (+56780A>G), rs3798234 (+75687C>T), rs9384970 (+68506G>A), rs1933739 (+72978G>A), and rs9400883 (+75809A>G)] in the FRK gene were determined by Affymetrix Targeted Genotyping Chip data. According to the classification of Korean Society for the Study of Obesity, control (BMI 18 to A) showed an association with overweight/obesity in the codominant model (p=0.03). Interestingly, the AA genotype distribution in the overweight/obesity group (n=7, 3.5%) was higher than those in the control group (n=1, 0.6%), which is not found in either Japanese or Chinese subjects. Therefore, the AA genotype of rs9384970 may be a risk factor for development of obesity in Korean population. The results suggest that FRK may be associated with overweight/obesity in Korean population.
机译：Fyn相关激酶（FRK）属于蛋白激酶的酪氨酸激酶家族。最近的研究表明，Frk在胚胎发生过程中影响胰腺β细胞的数量，并在响应链脲佐菌素时促进β细胞的细胞毒性信号。为了研究韩国人群中FRK多态性与肥胖风险之间的遗传关联，选择并分析了FRK基因区域的单核苷酸多态性（SNP）。计算体重指数（BMI），并测量每个受试者的血液样本的生化数据（收缩压，舒张压，血红蛋白A1C，甘油三酸酯，总胆固醇，高密度脂蛋白和低密度脂蛋白）。招募了155名健康对照者和204名超重/肥胖者。六个SNP的基因型频率[rs6568920（+ 8391G> A），rs3756772（+ 56780A> G），rs3798234（+ 75687C> T），rs9384970（+ 68506G> A），rs1933739（+ 72978G> A）和rs9400883（+通过Affymetrix靶向基因分型芯片数据确定FRK基因中的75809A> G）]。根据韩国肥胖症研究学会的分类，对照（BMI 18至A）在显性模型中显示出与超重/肥胖相关（p = 0.03）。有趣的是，超重/肥胖组的AA基因型分布（n = 7，3.5％）高于对照组（n = 1，0.6％），这在日本或中国受试者中均未发现。因此，rs9384970的AA基因型可能是韩国人群肥胖症发展的危险因素。结果表明，FRK可能与韩国人群的超重/肥胖有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号