• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Korean Journal of Physiology & Pharmacology >Pre-ischemic Treatment with Ampicillin Reduces Neuronal Damage in the Mouse Hippocampus and Neostriatum after Transient Forebrain Ischemia
【24h】

Pre-ischemic Treatment with Ampicillin Reduces Neuronal Damage in the Mouse Hippocampus and Neostriatum after Transient Forebrain Ischemia

机译：氨苄西林缺血前治疗减少短暂性前脑缺血后小鼠海马和新纹状体的神经元损伤

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ampicillin, a β-lactam antibiotic, has been reported to induce astrocytic glutamate transporter-1 which plays a crucial role in protecting neurons against glutamate excitotoxicity. We investigated the effect of ampicillin on neuronal damage in the mouse hippocampus and neostriatum following transient global forebrain ischemia. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral occlusion of the common carotid artery for 40 min. Ampicillin was administered post-ischemically (for 3 days) and/or pre-ischemically (for 3~5 days until one day before the onset of ischemia). Pre- and post-ischemic treatment with ampicillin (50 mg/kg/day or 200 mg/kg/day) prevented ischemic neuronal death in the medial CA1 area of the hippocampus as well as the neostriatum in a dose-dependent manner. In addition, ischemic neuronal damage was reduced by pre-ischemic treatment with ampicillin (200 mg/kg/day). In summary, our results suggest that ampicillin plays a functional role as a chemical preconditioning agent that protects hippocampal neurons from ischemic insult.
机译：据报道，氨苄青霉素是一种β-内酰胺抗生素，可诱导星形细胞谷氨酸转运蛋白1，后者在保护神经元免受谷氨酸兴奋性毒性中起着至关重要的作用。我们研究了短暂性前脑缺血后氨苄西林对小鼠海马和新纹状体神经元损伤的影响。用氟烷麻醉雄性C57BL / 6小鼠，并双侧阻断颈总动脉40分钟。氨苄青霉素在缺血后（3天）和/或缺血前（3〜5天，直到缺血发作前一天）给药。在使用氨苄青霉素（50 mg / kg /天或200 mg / kg /天）进行缺血前和缺血后治疗，可以剂量依赖性地预防海马内侧CA1区和新纹状体缺血性神经元死亡。此外，通过使用氨苄西林（200 mg / kg /天）进行缺血前治疗可以减少缺血性神经元损伤。总而言之，我们的研究结果表明氨苄西林作为一种化学预处理剂可以发挥功能性作用，保护海马神经元免受缺血性损伤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号