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首页> 外文期刊>Life sciences >Neuroprotective effects of grape seed extract on neuronal injury by inhibiting DNA damage in the gerbil hippocampus after transient forebrain ischemia
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Neuroprotective effects of grape seed extract on neuronal injury by inhibiting DNA damage in the gerbil hippocampus after transient forebrain ischemia

机译：葡萄籽提取物抑制短暂性前脑缺血后沙鼠海马DNA损伤对神经元损伤的神经保护作用

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摘要

Grape seed extract (GSE) possess cardioprotective abilities by functioning as in vivo antioxidants and by virtue of their ability to directly scavenge ROS including hydroxyl and peroxyl radicals. In the present study, we investigated the neuroprotective effects of grape seed extract (GSE) in the gerbil hippocampus after 5 min transient forebrain ischemia. Neuronal cell density in GSE-treated ischemic animals was significantly increased as compared with vehicle-treated ischemic animals 4 days after ischemic insult. In the GSE-treated groups, about 60% of pyramidal cells of the sham-operated group were stained with cresyl violet 4 days after ischemic insult. In this study, we found that GSE had neuroprotective effects on neuronal injury by inhibiting DNA damage in the CA1 region after ischemia. In vehicle-treated groups, 8-hydroxy-2'-deoxyguanosine (8-OHdG) immunoreactivity was significantly changed time-dependently, whereas the immunoreactivity in the GSE-treated group was similar to the sham-operated group. In addition, we confirmed that astrocytes and microglia did not show significant activation in the CA1 region 4 days after ischemia-reperfusion, because many CA1 pyramidal cells were not damaged. Therefore, these results suggest that GSE can protect ischemic neuronal damage by inhibiting DNA damage after transient forebrain ischemia. (C) 2004 Published by Elsevier Inc.
机译：葡萄籽提取物（GSE）具有体内抗氧化剂的功能，并具有直接清除包括羟基和过氧自由基在内的ROS的能力，因此具有心脏保护作用。在本研究中，我们调查了葡萄籽提取物（GSE）在5分钟短暂前脑缺血后对沙鼠海马的神经保护作用。在缺血性损伤后4天，与用载体处理的缺血动物相比，在用GSE处理的缺血动物中神经元细胞密度显着增加。在GSE治疗的组中，假手术损伤后4天，假手术组的约60％的锥体细胞被甲酚紫染色。在这项研究中，我们发现GSE通过抑制缺血后CA1区的DNA损伤，对神经元损伤具有神经保护作用。在媒介物治疗组中，8-羟基-2'-脱氧鸟苷（8-OHdG）免疫反应性随时间显着变化，而GSE治疗组的免疫反应性与假手术组相似。此外，我们证实，缺血再灌注后4天，星形胶质细胞和小胶质细胞未在CA1区显示出明显的激活作用，因为许多CA1锥体细胞未受损。因此，这些结果表明，GSE可以通过抑制短暂性前脑缺血后的DNA损伤来保护缺血性神经元损伤。 （C）2004由Elsevier Inc.出版

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