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首页> 外文期刊>The Journal of toxicological sciences >Allyl isothiocyanate-induced changes in the distribution of white blood cells in rats
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Allyl isothiocyanate-induced changes in the distribution of white blood cells in rats

机译：异硫氰酸烯丙酯诱导的大鼠白细胞分布变化

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The main pungent component of wasabi ( Eutrema japonica ) is known to be isothiocyanate and its derivatives, volatile substances.? Allyl isothiocyanate (AITC) accounts for more than half of isothiocyanate derivatives.? However, there is a little information on the effects of AITC on the immune system by analyzing the number of white blood cells (WBCs) over the course of days of AITC administration.? In the present study, we studied the effects of AITC (dose=20 mg/kg body weight/day for 10 days, subcutaneous: s.c.) on the number of WBCs (total WBCs, lymphocytes, monocyte, neutrophil, basophil and eosinophil) and plasma corticosterone concentrations in adult male rats.? Administration of AITC decreased significantly the number of total WBCs on days 1-4 post s.c. injection by 25-27%.? Administration of AITC also decreased the number of lymphocytes on days 1-10 by 21-36% and monocyte on days 1-8 by 28-78%.? However, administration of AITC increased the number of neutrophil on days 8-10 by 61-112%.? AITC did not change the number of eosinophil and basophil.? Plasma corticosterone concentrations during the experimental period were 4.7-8.4 times significantly higher in the AITC group than in the control group, indicating that AITC induced stress-responses.? The relative weights of thymus and adrenals per body weight were significantly lower and clearly higher in the AITC group than in the control group, respectively.? These results suggest that AITC-mediated stress-responses are at least in part attributable to changes in the number of circulating WBCs.
机译：芥末（Eutrema japonica）的主要刺激性成分是异硫氰酸酯及其衍生物，挥发性物质。异硫氰酸烯丙酯（AITC）占异硫氰酸酯衍生物的一半以上。但是，通过分析在服用AITC的过程中白细胞（WBC）的数量，关于AITC对免疫系统影响的信息很少。在本研究中，我们研究了AITC（剂量= 20 mg / kg体重/天，持续10天，皮下：皮下注射）对白细胞总数（白细胞总数，淋巴细胞，单核细胞，中性粒细胞，嗜碱性粒细胞和嗜酸性粒细胞）的影响，以及成年雄性大鼠血浆皮质酮浓度。在s.c.后1-4天，使用AITC可以显着减少白细胞总数。注射25-27％。 AITC的使用还使第1-10天的淋巴细胞数量减少了21-36％，而第1-8天的单核细胞数量减少了28-78％。但是，AITC的使用使第8-10天的中性粒细胞数量增加了61-112％。 AITC并没有改变嗜酸性粒细胞和嗜碱性粒细胞的数量。在AITC组实验期间血浆皮质激素浓度比对照组高4.7-8.4倍，表明AITC诱导了应激反应。与对照组相比，AITC组的胸腺和肾上腺每单位体重的相对重量分别显着降低和明显升高。这些结果表明，AITC介导的应激反应至少部分归因于循环中白细胞数量的变化。

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