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首页> 外文期刊>The Journal of toxicological sciences >MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect
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MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect

机译：脱氧雪腐酚可抑制A549肺上皮细胞中MEIS3的表达，并抑制其有害作用

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摘要

Deoxynivalenol (DON) is an important Fusarium toxin of concern for food safety. The inhalation of powder contaminated with DON is possible and may cause lung toxicity. In this study, we analyzed the gene expression profile of A549 cells treated for 24 hr with 0.2 μg/mL DON by microarray analysis. In total, 16 genes and 5 noncoding RNAs were significantly affected by DON treatment. The repression of B3GALT4 , MEIS3 , AK7 , SEMA3A , KCNMB4 , and SCARA5 was confirmed by quantitative PCR. We investigated the DON toxicity on A549 cells that exogenously expressed these 6 genes. The result indicated that A549 cells that transiently expressed MEIS3 were tolerant to the deleterious effects of DON. Our data show that DON affected the expression of genes with various functions, and suggest that the repression of MEIS3 plays roles in the deleterious effect of DON in A549 lung epithelial cells.
机译：脱氧雪腐烯酚（DON）是一种重要的食品安全性镰刀菌毒素。吸入被DON污染的粉末是可能的，并且可能引起肺毒性。在这项研究中，我们通过微阵列分析分析了用0.2μg/ mL DON处理24小时的A549细胞的基因表达谱。总计，DON处理显着影响了16个基因和5个非编码RNA。通过定量PCR证实了对B3GALT4，MEIS3，AK7，SEMA3A，KCNMB4和SCRA5的抑制。我们调查了DON对外源表达这6个基因的A549细胞的毒性。结果表明，瞬时表达MEIS3的A549细胞耐受DON的有害作用。我们的数据表明，DON影响具有各种功能的基因的表达，并表明MEIS3的抑制在DON对A549肺上皮细胞的有害作用中起作用。

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