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首页> 外文期刊>The Journal of toxicological sciences >Emergence of delayed behavioral effects in offspring mice exposed to low levels of mercury vapor during the lactation period
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Emergence of delayed behavioral effects in offspring mice exposed to low levels of mercury vapor during the lactation period

机译：在哺乳期暴露于低水平汞蒸气的后代小鼠中行为延迟行为的出现

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This study examined the emergence of delayed behavioral effects in offspring mice exposed to low levels of mercury vapor (Hg0) during the lactation period. Female offspring of mice were repeatedly exposed to Hg0 at 0.057 mg/m3, similar to the current threshold value (TLV), for 24 hr until the 20th day postpartum. The behavioral effects were evaluated with locomotor activity in the open field (OPF), learning activity in the passive avoidance response (PA) and spatial learning ability in the Morris water maze (MM) at the ages of 3 and 15 months. Hg0-exposed mice did not differ from controls in the three behavioral measurements at 3 months of age, and no neurobehavioral effects were observed. On the other hand, the mice exhibited significantly more central locomotion in the OPF task when tested at 15 months of age, but no abnormality in other behavioral performance. Immediately after postnatal exposure, the brain mercury concentration of offspring was about 150 times that of the control, in which the concentrations were approximately 0.4 μg/g. The results indicate that mice exposed to Hg0 at concentrations around TLV during the developing period resulted in the emergence of delayed behavioral effects at a later stage in life.
机译：这项研究检查了在哺乳期暴露于低水平汞蒸气（Hg 0 ）的后代小鼠中行为延迟行为的出现。将小鼠雌性后代反复暴露于0.057 mg / m 3 的Hg 0 ，类似于当前的阈值（TLV），持续24小时，直到20 产后一天。在3个月和15个月大的时候，通过开放领域的运动活动（OPF），被动回避反应的学习活动（PA）和莫里斯水迷宫（MM）的空间学习能力对行为影响进行了评估。暴露于Hg 0 的小鼠在3个月大的三个行为测量中与对照组没有差异，并且未观察到神经行为的影响。另一方面，在15个月大时进行测试时，小鼠在OPF任务中表现出明显更多的中枢运动，但其他行为表现没有异常。出生后立即暴露，后代的脑汞浓度约为对照的150倍，后者的浓度约为0.4μg/ g。结果表明，小鼠在发育期间暴露于TLV左右浓度的Hg 0 会导致生命后期出现延迟的行为效应。

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