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首页> 外文期刊>The Journal of toxicological sciences >High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats
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High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats

机译：高果糖饮食喂养可促进自发性糖尿病鸟（SDT）大鼠的糖尿病肾病

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摘要

Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple carbohydrate that is present in fruits and honey and is used as a sweetener because of its sweet taste. Fructose has been reported to have the potential to progress diabetes and DN in humans even though fructose itself does not increase postprandial plasma glucose levels. In this study, we investigated the effects of high fructose intake on the kidney of the Spontaneously Diabetic Torii (SDT) rats which have renal lesions similar to those in DN patients and compared these with the effects in normal SD rats. This study revealed that a 4-week feeding of the high fructose diet increased urinary excretion of kidney injury makers for tubular injury and accelerated mainly renal tubular and interstitial lesions in the SDT rats but not in normal rats. The progression of the nephropathy in the SDT rats was considered to be related to increased internal uric acid and blood glucose levels due to the high fructose intake. In conclusion, high fructose intake exaggerated the renal lesions in the SDT rats probably due to effects on the tubules and interstitium through metabolic implications for uric acid and glucose.
机译：糖尿病肾病（DN）是糖尿病的并发症之一，现在是终末期肾脏疾病的最常见原因。果糖是一种简单的碳水化合物，存在于水果和蜂蜜中，由于其甜味而被用作甜味剂。据报导，即使果糖本身不增加餐后血浆葡萄糖水平，但果糖仍可能使人患上糖尿病和DN。在这项研究中，我们调查了高果糖摄入量对自发性糖尿病鸟（SDT）大鼠肾脏的影响，该大鼠的肾脏病变与DN患者相似，并将其与正常SD大鼠的肾脏相比较。这项研究表明，高果糖饮食喂养4周可增加肾小管损伤性肾脏制造者的尿排泄，并主要加速SDT大鼠的肾小管和间质病变，而正常大鼠则不然。由于高果糖摄入，SDT大鼠肾病的进展被认为与体内尿酸和血糖水平升高有关。总之，果糖摄入过多可能是由于SDT大鼠尿酸和葡萄糖的代谢作用对肾小管和间质的影响而导致肾脏病变的扩大。

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