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首页> 外文期刊>The Journal of toxicological sciences >Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats
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Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats

机译：十溴化二苯醚暴露对成年Sprague-Dawley大鼠空间学习和记忆，海马谷氨酸受体亚单位表达和磷酸化的影响

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Previous studies have reported the potential developmental neurobehavioral effects of decabrominated diphenyl ethers (BDE 209) on developing animals, but the effects on adult animals are rare or controversial and the mechanism is not fully understood. In the present study, male adult Sprague-Dawley rats performed poor spatial learning and memory in Morris water maze after exposure to BDE 209 by gavage for 30 days. The expression of hippocampal glutamate receptor subunits NR1, NR2B and GluR1, the phosphorylation of NR2B subunit at Ser1301 (p-NR2B Ser1303) and GluR1 subunit at Ser831 (p-GluR1 Ser831) were all decreased, and the phosphorylation ratio of NR2B revealed an increasing trend after BDE 209 exposure. The present study provided evidence that BDE 209 could induce spatial learning and memory deficits in adult rats, and further explored the potential mechanism.
机译：先前的研究报道了十溴代二苯醚（BDE 209）对发育中的动物的潜在发育神经行为的影响，但对成年动物的影响却很少或有争议，其机理尚不完全清楚。在本研究中，雄性成年Sprague-Dawley大鼠通过管饲法暴露于BDE 209 30天后，在Morris水迷宫中进行了较差的空间学习和记忆。海马谷氨酸受体亚基NR1，NR2B和GluR1的表达，Ser1301的NR2B亚基（p-NR2B Ser1303）和Ser831的GluR1亚基（p-GluR1 Ser831）均降低，并且NR2B的磷酸化率增加BDE 209暴露后的趋势。本研究提供了证据，表明BDE 209可以诱导成年大鼠的空间学习和记忆障碍，并进一步探讨了其潜在机制。

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