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Pandemic Influenza

机译：大流行性流感

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摘要

Influenza viruses cause annual epidemics and occasional pandemics that have claimed the lives of millions. The emergence of novel strains continues to challenge the public health and scientific communities. Recent outbreaks of highly pathogenic avian influenza A virus infections (including those of the H5N1 subtype) in poultry and in humans (through contact with infected birds), since 2003, have had important economic repercussions and have raised concerns that a new influenza pandemic involving H5N1 viruses is imminent. In the spring of 2009, a novel swine-origin H1N1 virus, whose antigenicity is quite different from those of human H1N1 strains, emerged in Mexico and readily transmitted and spread among humans, resulting in international outbreaks. This H1N1 virus was shown to be a triple reassortant comprising genes derived from avian, human, and swine viruses. On 11 June 2009, the World Health Organization declared that the infection caused by this new strain had reached pandemic proportion. Here, we review our current knowledge of pandemic influenza.
机译：流感病毒导致每年的流行病和偶发的流行病夺走了数百万人的生命。新型菌株的出现继续挑战公共卫生和科学界。自2003年以来，最近在禽类和人类中（通过与感染禽类接触）爆发了高致病性甲型流感病毒感染（包括H5N1亚型），这对经济产生了重大影响，并引起了人们对涉及H5N1的新型流感大流行的担忧病毒迫在眉睫。 2009年春季，墨西哥出现了一种新型的猪源性H1N1病毒，其抗原性与人类H1N1株的抗原性完全不同，并易于在人类之间传播和传播，从而导致国际爆发。该H1N1病毒显示为三重重配体，包含源自禽，人和猪病毒的基因。 2009年6月11日，世界卫生组织宣布由这种新菌株引起的感染已达到大流行的比例。在这里，我们回顾了我们目前对大流行性流感的认识。

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