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首页> 外文期刊>The Open Anesthesia Journal >Effect of Midazolam and 0.5% Levobupivacaine Combination in Ultrasound-guided Supraclavicular Brachial Plexus Block for Upper Limb Surgeries - A Clinical Study
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Effect of Midazolam and 0.5% Levobupivacaine Combination in Ultrasound-guided Supraclavicular Brachial Plexus Block for Upper Limb Surgeries - A Clinical Study

机译：咪唑安定和0.5％左旋布比卡因联合使用在超声引导下锁骨上臂臂丛神经阻滞上肢手术的临床研究

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Background:The present study was designed to evaluate the hypothesis that midazolam as an adjuvant to levobupivacaine would safely enhance the duration of analgesia without any adverse effects when compared with levobupivacaine alone, in ultrasound-guided supraclavicular brachial plexus block. Primary end points were the duration of sensory and motor block and secondary end points were sedation score and any other complications.Patients and Method:Eighty consenting patients of both sexes, aged 18-60 years of ASA physical status I-II were randomized into two groups of 40 patients each. Patients in Group LS received 19 ml of 0.5% levobupivacaine with 1 ml normal saline and patients in Group LM received 19 ml of 0.5% levobupivacaine with 1ml midazolam (50μg/kg) for supraclavicular brachial plexus block using ultrasound guidance. Onset time and duration of sensory and motor blockade and VAS scores were assessed as primary end points. Hemodynamic changes, sedation or any other drug or technique related adverse effects were taken as secondary effects.Results:Onset of sensory and motor blockade was lower in patients of Group LM. The mean duration of sensory analgesia was significantly prolonged in patients of Group LM (537.6 ± 101.01 vs . 319.80 ± 87.09 mins). The mean duration of motor blockade was also significantly enhanced in patients of Group LM (405.0 ± 61.62 mins) compared to Group LS (274.8 ± 46.30 mins). VAS scores were higher in Group LS than group LM. Sedation scores were similar in both the groups.Conclusion:Midazolam with 0.5% levobupivacaine has effectively enhanced the duration of sensory and motor block without significant sedation and any other side effect.
机译：背景：本研究旨在评估以下假设：在超声引导的锁骨上臂丛神经阻滞中，咪达唑仑作为左旋布比卡因的佐剂与单独使用左旋布比卡因相比可安全地延长镇痛持续时间，而没有任何不利影响。主要终点为感觉和运动阻滞的持续时间，次要终点为镇静评分和任何其他并发症。患者与方法：将年龄在18-60岁的ASA身体状况I-II的80名男女同意患者随机分为两部分每组40名患者。 LS组患者在超声引导下接受锁骨上臂臂丛神经阻滞接受19 ml 0.5％左旋布比卡因和1 ml生理盐水，LM组患者接受19 ml的0.5％左旋布比卡因和1ml咪达唑仑（50μg/ kg）。感觉和运动阻滞的发作时间和持续时间以及VAS评分被评估为主要终点。血流动力学改变，镇静或任何其他药物或技术相关的不良反应为次要作用。结果：LM组患者的感觉和运动阻滞发作较低。 LM组患者的平均感觉镇痛持续时间明显延长（537.6±101.01 vs. 319.80±87.09分钟）。与LS组（274.8±46.30分钟）相比，LM组（405.0±61.62分钟）患者的平均运动阻滞持续时间也显着延长。 LS组的VAS评分高于LM组。结论：咪达唑仑含0.5％左旋布比卡因可有效延长感觉和运动阻滞的持续时间，而无明显的镇静作用和任何其他副作用。

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