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首页> 外文期刊>The Journal of Reproduction and Development >Follicular Persistence Induced by Adrenocorticotropic Hormone Administration in Goats
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Follicular Persistence Induced by Adrenocorticotropic Hormone Administration in Goats

机译：促肾上腺皮质激素给药对山羊卵泡的持久性的影响

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The objective of the present study was to examine the effect of adrenocorticotropic hormone (ACTH) administration on the induction of persistent cystic follicle in the goat in order to establish a method to experimentally induce cystic follicle. Four cross-bred goats were intramuscularly administered ACTH at 0.78 and 6.25 μ g/10 kg twice a day from Days 15 to 21 (Day 0 was defined as the day of last estrus). Follicular status in the ovary was monitored by ultrasound examination. The plasma concentrations of estradiol, progesterone and cortisol were measured. Treatment with ACTH at the 0.78 and 6.25 μ g/10 kg levels caused persistent follicles (> 10 days delay from the expected ovulation date) in 50% of the goats in both treatment groups. In those animals, ovulation occurred 17 and 27 days and 11 and 12 days after the expected days in the 0.78 and 6.25 μ g/10 kg groups, respectively. The maximum follicle diameters were 10 and 9 mm in the 0.78 and 6.25 μ g/10 kg ACTH groups, respectively. In the control group, the estradiol concentration increased on Day 18 and remained at a high level for a few days. However, such an increase was not seen in both ACTH groups. The estradiol concentration increased gradually from Days 21 to 27 in the 6.25 μ g/10 kg ACTH group. These results suggest the possibility that ACTH induces persistent follicles in goats, which may be related to the delay of the onset of estradiol secretion followed by its maintenance at a high concentration.
机译：本研究的目的是研究促肾上腺皮质激素（ACTH）诱导山羊持续性囊性卵泡的作用，以建立实验性诱导囊性卵泡的方法。从第15天到第21天（每天第0天定义为末次发情日），每天两次以0.78和6.25μg / 10 kg的剂量肌肉内对四只杂交山羊进行肌肉内给药。通过超声检查监测卵巢的卵泡状态。测量血浆雌二醇，孕酮和皮质醇的浓度。两个治疗组中有50％的山羊用0.78和6.25μg/ 10 kg水平的ACTH处理导致了持续的卵泡（从预期排卵日期延迟了10天以上）。在那些动物中，排卵发生在预期日数分别为0.78和6.25μg/ 10 kg组的第17天和27天以及第11天和第12天。在0.78和6.25μg/ 10 kg ACTH组中，最大卵泡直径分别为10和9 mm。在对照组中，雌二醇浓度在第18天增加，并在几天内保持在高水平。但是，两个ACTH组均未见这种增加。在6.25μg/ 10 kg ACTH组中，雌二醇浓度从第21天逐渐增加到第27天。这些结果表明ACTH可能在山羊中诱导持续的卵泡，这可能与延迟雌二醇分泌开始并随后保持高浓度有关。

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