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首页> 外文期刊>The Journal of Reproduction and Development >Endocrine Mechanisms Responsible for Different Follicular Development During the Estrous Cycle in Hatano High- and Low-avoidance Rats
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Endocrine Mechanisms Responsible for Different Follicular Development During the Estrous Cycle in Hatano High- and Low-avoidance Rats

机译：波多野高和低回避大鼠发情周期内不同卵泡发育的内分泌机制。

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Hatano high- and low-avoidance rats (HAA and LAA strains, respectively) were selected and bred according to the avoidance rate in a shuttle-box task. Although they have clear strain differences in ovarian function, their endocrine mechanisms still remain to be clarified. Differences in female reproductive endocrinology between the strains were investigated by means of measuring the plasma concentration of reproductive hormones during the estrous cycle. LAA rats showed approximately threefold lower basal and surge levels of LH, a more than fourfold lower level of FSH surges and higher levels of inhibin A and inhibin B during the estrous cycle compared with the levels seen in HAA rats. The concentration of estradiol-17β in the proestrous stage was significantly lower in LAA rats than in HAA rats. Additionally, LH and FSH secretions from primary cultured anterior pituitary cells with or without in vitro GnRH stimulation were lower in the cells derived from LAA rats and, in terms of FSH secretion, were unresponsive to GnRH in contrast to cells derived from HAA rats. Although an increased number of preantral follicles in diestrus were observed in LAA rats, number of hCG-induced ovulation was lower in LAA rats. LAA rats may have much more follicle growth during the early stage of folliculogenesis, but most follicles might not grow into mature follicles. These results strongly suggest that the strain difference in ovarian function of these two Hatano rats is due to the difference in the regulation of hypothalamo-hypophyseal system for gonadotropins secretion.
机译：选择了Hatano高回避和低回避大鼠（分别为HAA和LAA品系），并按照梭箱任务中的回避率进行繁殖。尽管它们在卵巢功能上有明显的应变差异，但是它们的内分泌机制仍有待阐明。通过测量发情周期中生殖激素的血浆浓度，研究了这些菌株之间女性生殖内分泌学的差异。与在HAA大鼠中观察到的水平相比，在发情周期中，LAA大鼠的LH的基础水平和喘振水平降低了约三倍，FSH激增的水平降低了四倍以上，抑制素A和抑制素B的水平更高。 LAA大鼠在发情期的雌二醇-17β浓度明显低于HAA大鼠。另外，在有或没有体外GnRH刺激的情况下，原代培养的垂体前叶细胞的LH和FSH分泌在LAA大鼠来源的细胞中较低，就FSH分泌而言，与HAA大鼠来源的细胞相比，对GnRH无反应。尽管在LAA大鼠中观察到二头肌的窦前卵泡数量增加，但hCG诱导的排卵数在LAA大鼠中较低。 LAA大鼠在卵泡形成的早期阶段可能具有更多的卵泡生长，但是大多数卵泡可能不会长成成熟的卵泡。这些结果强烈表明，这两只波多野大鼠的卵巢功能的应变差异是由于下丘脑-垂体系统对促性腺激素分泌的调节差异所致。

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