Crystallization and Preliminary X-Ray Crystallographic Studies of a Myotoxic Lys49-phospholipase A2 from Bothrops jararacussu Venom Complexed with α-Tocopherol Inhibitorm

Agnes A.S. Takeda; Juliana I.dos Santos; Daniela P.Marchi-Salvador; Andreimar M.Soares; Marcos R.M.Fontes

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Crystallization and Preliminary X-Ray Crystallographic Studies of a Myotoxic Lys49-phospholipase A2 from Bothrops jararacussu Venom Complexed with α-Tocopherol Inhibitorm

机译：结晶和初步X射线晶体学研究的肌肉毒素Lys49磷脂酶A2的从Bothrops jararacussu毒液与α-生育酚抑制剂复合的。

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Bothropstoxin I (BthTX-I), a non-catalytic and myotoxic Lys49-PLA2 from Bothrops jararacussu venom, hasbeen crystallized alone and complexed with α-tocopherol inhibitor. These crystals have been shown to diffract X-rays between2.17 and 1.83 ? resolution. The BthTX-I/α-tocopherol complex crystals are not isomorphous with those of the nativeprotein. This suggests the inhibitor binding has lead to changes in the quaternary structure and a different conformationmay have been obtained.

机译：Bothropstoxin I（BthTX-I）是一种非催化的且对肌有毒的Lys49-PLA2，来自Bothrops jararacussu毒液，已单独结晶并与α-生育酚抑制剂复合。已经证明这些晶体在2.17和1.83之间衍射X射线。解析度。 BthTX-1 /α-生育酚复合物晶体与天然蛋白的晶体不同。这表明抑制剂的结合导致了四级结构的改变，并且可能获得了不同的构象。

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《The Open Crystallography Journal》 |2008年第1期|共4页
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Agnes A.S. Takeda; Juliana I.dos Santos; Daniela P.Marchi-Salvador; Andreimar M.Soares; Marcos R.M.Fontes;
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6. Crystallization and Preliminary X-Ray Crystallographic Studies of a Myotoxic Lys49-phospholipase A2 from Bothrops jararacussu Venom Complexed with α-Tocopherol Inhibitor [O] . Marcos R. M. Fontes, Agnes A. S. Takeda, Juliana I. dos Santos, 2008

机译：来自Bothrops Jararacussu毒液与α-生育酚抑制剂络合的肌毒性Lys49-磷脂酶A2的结晶和初步X射线晶体研究

Crystallization and Preliminary X-Ray Crystallographic Studies of a Myotoxic Lys49-phospholipase A2 from Bothrops jararacussu Venom Complexed with α-Tocopherol Inhibitorm

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