• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Open Drug Delivery Journal >Designing of a Thermosensitive Chitosan/Poloxamer In Situ Gel for OcularDelivery of Ciprofloxacin
【24h】

Designing of a Thermosensitive Chitosan/Poloxamer In Situ Gel for OcularDelivery of Ciprofloxacin

机译：用于眼内递送环丙沙星的热敏壳聚糖/泊洛沙姆原位凝胶的设计

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To increase the low bioavailability and short ocular residence time of ciprofloxacin eye drops, aqueous solutionsof drug in chitosan/ Pluronic (poloxamer) were prepared to identify suitable compositions with regard to gel formingproperties and drug release behavior. Mixtures of solutions of Pluronic (10-25% w/w) with chitosan (0.1-0.3% w/w) ofdifferent molecular weights (Mw) were prepared. Ciprofloxacin release was determined using a membraneless dissolutionmodel in artificial tear solution up to 8 hours and the samples were analyzed spectrophotometrically at 272.4nm. Therheological behavior of solutions in response to dilution or temperature changes and also the phase change temperature(PCT) were determined using a Cup & Bob viscometer. Antimicrobial effect of the solutions was studied in nutrient agarin comparison to marketed solutions of ciprofloxacin using Pseudomonas aueroginosa and Staphylococcus aureus by theagar diffusion test using the cup-plate technique. The formulation consisted of 15% Pluronic and 0.1% low Mw chitosan,with the highest release efficiency (46.61 ± 0.41%) and an acceptable mean release time (1.94 ± 0.27 hr), is suggested as asuitable ophthalmic preparation for sustained release of ciprofloxacin. This in situ gel released the drug by a Higuchimodel and Fickian mechanism. It was liquid in non-physiologic conditions (pH 4 and 25oC) and transferred to the gelform upon physiologic conditions (pH 7.4 and 37oC). The PCT of this in situ gel did not change upon dilution and thezone of inhibition of the growth of both studied bacteria was significantly greater for it than the marketed eye drop ofciprofloxacin.
机译：为了增加环丙沙星滴眼液的低生物利用度和较短的眼部停留时间，制备了壳聚糖/ Pluronic（泊洛沙姆）中药物的水溶液，以鉴定关于凝胶形成性质和药物释放行为的合适组合物。制备了Pluronic（10-25％w / w）与不同分子量（Mw）的壳聚糖（0.1-0.3％w / w）溶液的混合物。使用无膜溶解模型在人工泪液中长达8小时测定环丙沙星的释放，并在272.4nm处用分光光度法分析样品。使用Cup＆Bob粘度计测定溶液对稀释或温度变化的响应，以及相变温度（PCT）的流变行为。在营养琼脂中与市售的环丙沙星溶液（分别使用假单胞菌和金黄色葡萄球菌）进行比较，并通过杯板技术进行茶蜡扩散测试，研究了该溶液的抗菌作用。建议该制剂由15％的Pluronic和0.1％的低分子量壳聚糖组成，具有最高的释放效率（46.61±0.41％）和可接受的平均释放时间（1.94±0.27 hr），被推荐作为持续释放环丙沙星的眼科制剂。这种原位凝胶通过Higuchimodel和Fickian机制释放了药物。在非生理条件下（pH 4和25oC）呈液态，在生理条件下（pH 7.4和37oC）转移至凝胶状。该原位凝胶的PCT在稀释后没有变化，并且对这两种研究细菌的生长的抑制范围明显大于市售的环丙沙星滴眼液。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号