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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Design and evaluation of a multifunctional thermosensitive poloxamer-chitosan-hyaluronic acid gel for the treatment of skin burns
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Design and evaluation of a multifunctional thermosensitive poloxamer-chitosan-hyaluronic acid gel for the treatment of skin burns

机译：用于治疗皮肤烧伤的多功能热敏泊洛昔洛昔洛昔氨酰基 - 透明质酸凝胶的设计与评价

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摘要

The main goal of this study was the design, development and characterization of a poloxamer/chitosan/hyaluronic based vehicle including three biological antioxidant molecules such as vitamins A, D and E aimed at improving the treatment of skin burns. The physical characterization of hydrogel, its mechanical and rheological properties as well as internal structure were investigated. Furthermore, biological characteristics such as ex vivo antimicrobial properties and in vivo wound healing were also accomplished and compared with a commercial reference. Results showed optimal physicochemical properties with biocompatible pH value of 4.6 +/- 0.1 and zeta potential dependent on pH. The swelling rate was around 350% with optimal wettability, adhesion and leakage properties, as well as thermosensitive gelation processes. The microbiological assay demonstrated similar antimicrobial activity to that of commercial reference. In vivo tolerance study revealed no skin reactions. Finally, the wound healing efficacy of hydrogel in skin burn model showed dermal appendages and similar epidermis, dermis and stratum corneum to the commercial reference. These findings indicated that our hydrogel loading vitamins could be considered an outstanding candidate for further clinical studies. (C) 2019 Elsevier B.V. All rights reserved.
机译：本研究的主要目的是脊杀酰胺/壳聚糖/透明质酸的车辆的设计，开发和表征，包括三种生物抗氧化分子，例如维生素A，D和E，旨在改善皮肤灼伤的治疗。研究了水凝胶的物理表征，其机械和流变性能以及内部结构。此外，还可以实现和体内伤口愈合等生物学特性，并与商业参考进行比较。结果表明，具有4.6 +/- 0.1和依赖于pH的Zeta电位的生物相容性pH值的最佳物理化学性质。膨胀率约为350％，具有最佳的润湿性，粘附和泄漏性能，以及热敏胶凝过程。微生物测定表现出与商业参考的类似抗微生物活性。体内耐受性研究显示没有皮肤反应。最后，皮肤燃烧模型中水凝胶的伤口愈合效果显示了真皮阑尾和类似的表皮，真皮和地层基层与商业参考。这些发现表明，我们的水凝胶负载维生素可以被认为是进一步临床研究的杰出候选者。 （c）2019 Elsevier B.v.保留所有权利。

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