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Effect of Vehicles on Release of Meloxicam from Various Topical Formulations

机译：载剂对各种局部用药制剂中美洛昔康释放的影响

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This article evaluates the effect of various vehicles (O/W, W/O and two W/O/W emulsions and a hydrogel) on meloxicam release. One of W/O/W emulsions was named W/O/W-C containing Carbopol? 934 as a gelling agent in its outer aqueous phase. Release of drug through cellulose acetate membrane was studied by using Franz-type diffusion cells. Hydrogel formulation gave the highest release with a significant difference followed by W/O/W, O/W, W/O/W-C and W/O emulsions. Increase in amount of oil phase resulted in slower drug release strictly indicating importance of lipophility of vehicle on release of lipophilic drugs like MX. Incorporation of MX in hydrogel increased the released amount by up to 20 times when compared with the other formulations. Increase in viscosity of the formulations was also followed the same order. Release study was performed by using UV spectroscopy. Furthermore, the determination method of MX was validated through the following performance criteria: linearity, intra-day and inter-day precision, accuracy, specifity and recovery. This method was proved as precise and accurate determination of MX in multi-component pharmaceutical preparations besides colorimetric methods.
机译：本文评估了各种载体（O / W，W / O和两种W / O / W乳剂和水凝胶）对美洛昔康释放的影响。一种W / O / W乳液被命名为含Carbopol®的W / O / W-C。 934在其外部水相中用作胶凝剂。使用Franz型扩散池研究了药物通过醋酸纤维素膜的释放。水凝胶制剂以最高的释放率具有显着差异，其次是W / O / W，O / W，W / O / W-C和W / O乳液。油相量的增加导致药物的释放较慢，严格表明媒介物的亲脂性对诸如MX的亲脂性药物的释放很重要。与其他配方相比，将MX掺入水凝胶可将释放量提高多达20倍。制剂的粘度增加也遵循相同的顺序。通过使用紫外光谱进行释放研究。此外，通过以下性能标准验证了MX的测定方法：线性，日间和日间精度，准确性，特异性和回收率。实践证明，该方法不仅比色法还可以准确，准确地测定多组分药物制剂中的MX。

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