Erythropoietin Levels in Cardiac Resynchronization Patients

Patrick Alexander; Ayad Jazrawi; Sarah Clifford; MartinSchmidt; MarcosDaccarett

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Erythropoietin Levels in Cardiac Resynchronization Patients

机译：心脏再同步患者的促红细胞生成素水平

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Cardiac resynchronization therapy (CRT) is indicated in patients with advanced heart failure secondary tosevere systolic impairment and refractory symptoms despite optimized medical treatment and evidence of electromechanicaldyssynchrony with a QRS complex greater than 120 milliseconds (msec). Approximately 20%-30% ofpatients who receive CRT fail to respond with little improvement in subjective symptoms, functional capacity, and leftventricular indices. To date, there fails to be a serologic marker to adequately assess the degree of ventriculardyssynchrony and electro-mechanical dissociation. Increased levels of erythropoietin (EPO), a hematopoietic cytokine,has been demonstrated in patients with more advanced stages of heart failure and is associated with an increase inmortality and hospital re-admission. A recent study demonstrated a significant response to CRT in patients with higherbaseline EPO levels (> 25mU/mL) with improvements in cardiac function and reduced heart failure symptoms. Thepresence of elevated EPO levels in addition to traditional determinants of cardiac dyssynchrony may effectively predictthose that will benefit from CRT.

机译：尽管进行了优化的药物治疗和QRS复合波大于120毫秒（msec）的证据表明，心脏重同步治疗（CRT）适用于继发于严重收缩压和收缩期症状继发的严重心力衰竭的患者。接受CRT的患者中约有20％-30％的患者在主观症状，功能能力和左心室指标方面无明显改善。迄今为止，还没有血清学标记物可以充分评估心室不同步和机电分离的程度。在具有较严重心力衰竭的患者中，已经证实了造血细胞因子促红细胞生成素（EPO）水平的升高，并与死亡率增加和住院率增加有关。最近的一项研究表明，基线EPO水平较高（> 25mU / mL）的患者对CRT的反应显着，其心脏功能得到改善，心力衰竭症状减轻。除传统的心脏不同步因素外，EPO水平升高还可能有效预测那些将从CRT中受益的因素。

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《The Open Drug Discovery Journal》 |2010年第1期|共3页
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Patrick Alexander; Ayad Jazrawi; Sarah Clifford; MartinSchmidt; MarcosDaccarett;
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1. Cardiac resynchronization therapy outcomes in patients with chronic heart failure: cardiac resynchronization therapy with pacemaker versus cardiac resynchronization therapy with defibrillator [J] . Drozd Michael, Gierula John, Lowry Judith E., Journal of cardiovascular medicine . 2017,第12期

机译：慢性心力衰竭患者的心脏重新同步治疗结果：心脏重新同步治疗起搏器与除颤器心脏重新同步治疗
2. Cardiac resynchronization therapy-defibrillator improves long-term survival compared with cardiac resynchronization therapy-pacemaker in patients with a class IA indication for cardiac resynchronization therapy: Data from the Contak Italian Registry [J] . MoraniG., GaspariniM., ZanonF., Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology . 2013,第9期

机译：与心脏再同步治疗-起搏器相比，心脏再同步治疗-除颤器可改善具有IA级心脏再同步治疗指征的患者的长期生存：来自Contak Italian Registry的数据
3. Effect on cardiac function of cardiac resynchronization therapy in patients with right bundle branch block (from the multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy [MADIT-CRT] trial) [J] . TompkinsC., KutyifaV., McNittS., The American Journal of Cardiology . 2013,第4期

机译：右束支传导阻滞患者对心脏再同步治疗心功能的影响（来自多中心自动除颤器植入试验和心脏再同步治疗[MADIT-CRT]试验）
4. Personalized Modeling Pipeline for Cardiac Electrophysiology Simulations of Cardiac Resynchronization Therapy in Infarct Patients [C] . Caroline Mendonca Costa, Aurel Neic, Gernot Plank, Computing in Cardiology Conference . 2018

机译：个性化建模管道，用于梗死患者心脏再同步治疗的心脏电生理模拟
5. Electrocardiographic imaging of paced sequences and infarct substrate in canine hearts, and in patients undergoing cardiac resynchronization therapy. [D] . Jia, Ping. 2004

机译：犬心脏以及接受心脏再同步治疗的患者中的起搏序列和梗塞底物的心电图成像。
6. Serum phosphate levels reflect responses to cardiac resynchronization therapy in chronic heart failure patients [O] . Yoshiyuki Kamiyama, Hitoshi Suzuki, Shinya Yamada, 2015

机译：血清磷酸盐水平反映了慢性心力衰竭患者对心脏再同步治疗的反应
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Erythropoietin Levels in Cardiac Resynchronization Patients

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