...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Open Inflammation Journal >Definition of Inflammation, Causes of Inflammation and PossibleAnti-inflammatory Strategies
【24h】

Definition of Inflammation, Causes of Inflammation and PossibleAnti-inflammatory Strategies

机译：炎症的定义，炎症原因和可能的抗炎策略

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Current definition of inflammation by its cardinal signs is obsolete and unsuitable for guiding adequatetherapeutic strategies. Furthermore, present theory of the inflammatory process regarding vascular phenomena as essentialfor generation of cardinal signs is invalid and unable to explain well established empirical facts, particularly the extent ofthe osmotic pressure and temperature variations within the inflamed tissue.From five cardinal signs, there is actually just one specific macroscopic sign of inflammation, namely localized edema.Further, the driving force for tissue fluid accumulation is defined in biochemical terms and as such taken for the definitionof the inflammatory process. Inflammation may be defined as a degenerative process which is intense enough to causelocal accumulation of low molecular weight catabolic products, which in turn elevates tissue osmotic pressure that attractsextra fluid, with or without heat release sufficient for significant elevation of tissue temperature. This process is in a sharpcontrast to the pathogenesis of burns, where externally applied heat causes a process that is in essence opposite toinflammation, bearing only some superficial similarities with the latter.The inflammatory process is itself a pathological process, whereas the natural anti-inflammatory response that ensuesafter acute inflammation tends to reverse tissue homeostasis towards normality and should therefore be regarded as a truedefensive reaction of the affected tissue.Based on the therapeutic principle of reverse thermodynamics, heat application to the inflamed tissue is an obvious, yetnon-exclusive therapeutic choice that follows from the given universal definition of inflammation.
机译：目前通过其基本体征对炎症的定义已经过时，不适合指导适当的治疗策略。此外，目前关于以血管现象为基本信号产生必不可少的炎症过程的理论是无效的，并且无法解释已建立的经验事实，尤其是发炎组织内的渗透压和温度变化的程度。从五个基本信号来看，实际上有仅仅是炎症的一种具体的宏观体征，即局部性水肿。此外，组织液积聚的驱动力是用生化术语定义的，并以此来定义炎症过程。炎症可定义为退化过程，其强度足以引起低分子量分解代谢产物的局部积累，继而升高吸引组织的渗透压，而无论是否存在足以显着升高组织温度的热量释放。此过程与烧伤的发病机理形成鲜明对比，其中外部施加的热量导致与炎症本质上相反的过程，仅与炎症有一些表面上的相似之处。炎症过程本身是病理过程，而天然的消炎过程急性炎症后发生的反应倾向于使组织稳态逆转为正常状态，因此应被视为受影响组织的真正防御反应。基于逆向热力学的治疗原理，对发炎组织进行加热是一种明显但非排他性的治疗选择从给定的炎症通用定义得出。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号