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首页> 外文期刊>The Open Obesity Journal >Association of Changes in Body Composition with Changes in Systemic Oxidative Stress Following Weight Loss Program in Obese AdultsAttending Obesity Clinic, Hospital Universiti Sains Malaysia
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Association of Changes in Body Composition with Changes in Systemic Oxidative Stress Following Weight Loss Program in Obese AdultsAttending Obesity Clinic, Hospital Universiti Sains Malaysia

机译：肥胖成年人减肥计划后身体成分变化与全身氧化应激变化的关系马来西亚Sains大学医院肥胖症诊所

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The main objective of the present study was to evaluate the association of changes in body composition withchanges in systemic oxidative stress markers among obese adults participating in a weight loss program. Thirty four obeseadults were recruited from the Obesity Clinic, Hospital Universiti Sains Malaysia (USM) to voluntarily participate in aweight loss program comprising of physical exercise and dietary modification. Levels/activities of oxidative stressmarkers were measured before and after the program. Mean body weight, body mass index (BMI), waist circumference(WC), hip circumference (HC) and percentage of body fat mass decreased significantly while mean body lean mass andbody water increased significantly after the weight loss program. Plasma glutathione peroxidase (GPx) activity and 4-hydroxynonenal (4-HNE) concentration increased significantly while other enzymatic antioxidant activities such ascatalase (CAT) and superoxide dismutase (SOD) were not significantly increased. The ratio of reduced glutathione(GSH) to oxidized glutathione (GSSG) was significantly decreased. There was no significant association betweenchanges in body composition and changes in systemic oxidative stress markers among obese adults. In conclusion,changes in body composition were not associated with changes in systemic oxidative stress markers among obese adults.
机译：本研究的主要目的是评估参加减肥计划的肥胖成年人的身体组成变化与全身氧化应激指标变化之间的关系。从马来西亚大学医学院（USM）的肥胖诊所招募了34名肥胖患者，他们自愿参加了一项包括体育锻炼和饮食调节的减肥计划。在程序之前和之后测量氧化应激标记的水平/活性。减肥计划后，平均体重，体重指数（BMI），腰围（WC），臀围（HC）和体脂质量百分比显着下降，而平均瘦体重和体水显着增加。血浆谷胱甘肽过氧化物酶（GPx）活性和4-羟基壬醛（4-HNE）浓度显着增加，而其他酶促抗氧化活性，例如过氧化氢酶（CAT）和超氧化物歧化酶（SOD）则没有显着增加。还原型谷胱甘肽（GSH）与氧化型谷胱甘肽（GSSG）的比例显着降低。在肥胖成年人中，身体组成的变化与全身氧化应激标志物的变化之间没有显着关联。总之，肥胖成年人的身体组成变化与全身氧化应激指标的变化无关。

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