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首页> 外文期刊>The Open Obesity Journal >Noninvasive Quantification of Hepatic Steatosis: Relationship BetweenObesity Status and Liver Fat Content
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Noninvasive Quantification of Hepatic Steatosis: Relationship BetweenObesity Status and Liver Fat Content

机译：肝脂肪变性的非侵入性定量：肥胖状况和肝脂肪含量之间的关系

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The aim of this study was to assess and compare fat content within the liver for normal (body mass index(BMI) < 25 kg/m2), overweight (25-30 kg/m2) and obese (≥ 30 kg/m2) subjects using a noninvasive, non-contrastcomputed tomography (CT) quantification method. Adult subjects aged 18-60 yrs scheduled to undergo CT examinationof the abdominal region were recruited for this study, stratified across BMI categories. Liver volume, fat content, and leanliver volume were determined using CT methods. A total of 100 subjects were recruited, including 30 normal weight, 31overweight, and 39 obese. Total liver volume increased with BMI, with mean values of 1138 ± 277, 1374 ± 331, and 1766± 389 cm3 for the normal, overweight, and obese, respectively (P < 0.001), which was due to an increase in both liver fatcontent and lean liver volume with BMI. Some obese subjects had no or minimal hepatic fat content. The prevalence ofmild fatty liver in this study of 100 subjects was overestimated for all BMI categories using a range of qualitativediagnostic measures, with predicted prevalence of fatty liver in obese subjects ranging from 76.9% for liver-to-spleenratio ≤ 1.1 to 89.7% for liver attenuation index (liver HU - spleen HU) ≤ 40, compared to 66.7% by quantification of fatcontent. Results show that total liver volume increases with BMI, however, not all obese subjects display fatty infiltrationof the liver. CT quantification of liver fat content may be suitable for accurate diagnosis of hepatic steatosis in clinicalpractice and assessment of donor livers for transplantation.
机译：这项研究的目的是评估和比较正常（体重指数（BMI）<25 kg / m2），超重（25-30 kg / m2）和肥胖（≥30 kg / m2）受试者肝脏中的脂肪含量使用无创，非对比计算机断层扫描（CT）量化方法。本研究招募了计划接受腹部CT检查的18-60岁年龄段的成年人，并按BMI类别进行了分层。使用CT方法确定肝体积，脂肪含量和瘦肝体积。总共招募了100名受试者，包括30名正常体重，31名超重和39名肥胖。正常人，超重和肥胖者的总肝脏体积随BMI的增加而增加，平均值分别为1138±277、1374±331和1766±389 cm3（P <0.001），这是由于肝脏脂肪含量均增加并通过BMI瘦身肝脏。一些肥胖的受试者没有或仅有最小的肝脂肪含量。使用一系列定性诊断方法，对所有100名受试者的轻度脂肪肝患病率均高估了所有BMI类别，预计肥胖人群的脂肪肝患病率范围为76.9％（肝脏至脾脏≤1.1到89.7％）。衰减指数（肝脏HU-脾HU）≤40，相比之下，脂肪含量的定量指标为66.7％。结果显示，总的肝脏容量随BMI的增加而增加，但是，并非所有肥胖的受试者都表现出肝脏的脂肪浸润。肝脏脂肪含量的CT量化可能适合在临床实践中准确诊断肝脂肪变性和评估供体肝移植。

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