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首页> 外文期刊>The Open Nutraceuticals Journal >Memory Enhancement from Two Weeks’ Exposure to North AmericanGinseng Extract HT1001 in Young and Middle Aged Healthy Adults
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Memory Enhancement from Two Weeks’ Exposure to North AmericanGinseng Extract HT1001 in Young and Middle Aged Healthy Adults

机译：两周暴露于北美人参提取物HT1001的中青年健康成年人的记忆增强

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In vivo, in vitro, and animal learning studies have reported neuroactive effects of Rb1 and Rg1 ginsenosidesthat may be relevant to human learning and memory. The objective of this study was to assess potential learning andmemory benefits of HT1001, a standardized proprietary North American ginseng (Panax quinquefolius) extract containingRb1, Rg1 and other important ginsenosides, in healthy volunteers. Neuropsychological assessments were conductedusing the Clinical Memory Scale (CMS), which has two parallel forms for baseline and post-treatment assessments. Ayoung adult sample (YAS, n = 10) and a middle aged sample (MAS, n = 10) completed the CMS at baseline and again after14 days’ exposure to 200mg HT1001 daily. The CMS Memory Quotient (MQ) showed significant main effects oftime, with higher CMS-MQ on the second assessment compared to the first, and of age group, with the YAS performingbetter than the MAS. There was no interaction between time and age group. Secondary analyses indicated benefits forboth groups on free recall of word lists, cued recall of word pairs, and recognition of figures, and benefits in the YAS butnot the MAS on free recall of pictures. Taken together, the results suggest that memory, as measured with the CMS-MQ,was significantly improved with open-label HT1001. While practise effects cannot be completely ruled out, the resultspresented here are exciting and timely given our increasingly ageing population, and provide preliminary support for aprospective placebo-controlled examination of HT1001 on learning and memory.
机译：体内，体外和动物学习研究都报告了Rb1和Rg1人参皂甙的神经活性作用，这可能与人类的学习和记忆有关。这项研究的目的是评估健康志愿者HT1001（含Rb1，Rg1和其他重要人参皂甙的标准化北美专有人参（Panax quinquefolius）提取物）的潜在学习和记忆优势。神经心理学评估是使用临床记忆量表（CMS）进行的，该表具有两种平行形式的基线和治疗后评估。 Ayoung成人样本（YAS，n = 10）和中年样本（MAS，n = 10）在基线时以及在每天暴露于200mg HT1001 14天后再次完成了CMS。 CMS记忆商（MQ）表现出明显的主要时间影响，与第一次和年龄组相比，第二次评估的CMS-MQ更高，YAS的表现优于MAS。时间和年龄组之间没有互动。二级分析表明，对于自由召回单词列表，提示词对重新召唤和图形识别，这两个群体都受益，而在YAS中却对MAS带来了图片自由召回的好处。综上所述，结果表明，使用CMS-MQ进行测量时，使用开放标签HT1001可以显着改善内存。尽管不能完全排除实践影响，但鉴于我们的人口日趋老龄化，此处给出的结果令人兴奋且及时，并为HT1001在学习和记忆方面的前瞻性安慰剂对照检查提供了初步支持。

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