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首页> 外文期刊>The Open Obesity Journal >Adherence to a Diet and Exercise Weight Loss Intervention amongst Women at Increased Risk of Breast Cancer
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Adherence to a Diet and Exercise Weight Loss Intervention amongst Women at Increased Risk of Breast Cancer

机译：在罹患乳腺癌风险增加的女性中坚持饮食和运动减肥干预

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Maintained weight loss of five percent or more may reduce risk of breast cancer. We conducted a feasibility pilot study to assess adherence to an intensive 12 month diet and exercise weight control intervention aimed to achieve and maintain a five percent or greater weight loss as compared to a usual care group receiving written advice only. Overweight premenopausal women at increased risk of breast cancer were enrolled in a 12 month diet and exercise weight loss programme (n = 40) or a comparison group receiving usual care (n = 39). Changes in weight, general (DXA, bioelectrical impedance) and central adiposity (intra abdominal fat; MRI, waist), dietary intake, physical activity, cancer worry (Lerman score) and quality of life (SF-36) were assessed at 6 and 12 months, as well as long-term changes in weight and adiposity 12 and 42 months after the end of the intervention.Target weight loss (5%) was achieved by 55% of the intervention group at the end of the 12 month intervention but maintained by fewer at 24 (39%) and 54 months -(21%). Overall the intervention group achieved significant reductions in weight (mean [95% CI] -4.6 [-6.4 to -2.8] %), body fat (-4.0 [-5.2 to -2.7] ) kg, intra abdominal fat (-25.0 [-39.0 to -8.0])% and waist circumference (-4.0 [-6.8 to -2.0] cm) during the 12 month intervention and reported large reductions in intake of energy (-24.3 [-33.2 to -15.1] %), fat (-32 [-44 to -20] %), and alcohol (-35 [-52 to -13] %), and increased moderate activity (27 [7 to 44] minutes/day). These parameters did not change in the usual care group (all P < 0.05). A small proportion of the usual care group lost and maintained > 5% of their weight at 6 (16%), 12 (11%), 24 (11%) and 54 (13%) months (P < 0.05 at all time points). The intervention increased physical well being (SF-36; P < 0.05) but had no measurable effect on mental well being or cancer worry. Weight loss is achievable within our high risk women but not more so than in previous studies in the general population. Further studies are required to better understand factors which can promote compliance in women at increased risk of breast cancer.
机译：保持百分之五或更多的体重减轻可以降低患乳腺癌的风险。与仅接受书面建议的普通护理组相比，我们进行了可行性试点研究，以评估对强化12个月饮食和运动体重控制干预措施的依从性，旨在实现并保持5％或更多的体重减轻。患有乳腺癌风险增加的超重绝经前妇女参加了为期12个月的饮食和运动减肥计划（n = 40）或接受常规护理的对照组（n = 39）。体重，总体重（DXA，生物电阻抗）和中央肥胖（腹内脂肪; MRI，腰围），饮食摄入，身体活动，癌症担忧（Lerman评分）和生活质量（SF-36）的变化在6和干预结束后的12个月以及体重和肥胖的长期变化在干预结束后的12和42个月。在12个月的干预结束时，有55％的干预组实现了目标体重减轻（5％）减少了24个（39％）和54个月-（21％）。总体而言，干预组的体重（平均[95％CI] -4.6 [-6.4至-2.8]％），体脂（-4.0 [-5.2至-2.7]）kg，腹腔内脂肪（-25.0 [ -39.0至-8.0]）％和腰围（-4.0 [-6.8至-2.0] cm），据报道，脂肪的能量摄入大幅度减少（-24.3 [-33.2至-15.1]％），脂肪（-32 [-44至-20]％）和酒精（-35 [-52至-13]％），并增加中度活动（27 [7至44]分钟/天）。在常规治疗组中，这些参数没有改变（所有P <0.05）。一小部分常规护理组在6（16％），12（11％），24（11％）和54（13％）个月时体重减轻并保持> 5％（在所有时间点P <0.05 ）。干预增加了身体健康（SF-36; P <0.05），但对精神健康或癌症担忧没有可测量的影响。在我们的高危女性中，体重减轻是可以实现的，但与普通人群中以前的研究相比，减肥的幅度不大。需要进行进一步的研究以更好地理解可以促进女性罹患乳腺癌风险增加的依从性的因素。

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