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首页> 外文期刊>The Open Obesity Journal >Association of Components of Metabolic Syndrome with Depression and Anxiety in Patients Undergoing Weight Reduction Surgery
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Association of Components of Metabolic Syndrome with Depression and Anxiety in Patients Undergoing Weight Reduction Surgery

机译：减肥手术患者代谢综合征成分与抑郁和焦虑的关系

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Background: Obesity can be associated with psychiatric disorders such as depression. Aim: To determine the prevalence and association of psychiatric disorders in patients with excess body weight. Methods: Patients scheduled for weight reduction surgery were included. For each patient, pre-surgical clinical and psychiatric data were collected. Follow-up data were available 1-year after surgery. Patients with psychiatric disorders were compared to those without psychiatric disorders. Mann-Whitney non-parametric test was used for comparison of numerical parameters, while prevalence of certain clinical and demographic events were validated using chi-square homogeneity test. Results: 499 patients were included: age: 42.8 ±11.0 years, 20% male, 76% Caucasians, BMI 46.8 ± 10.8, ALT 32.5 ± 21.7 and AST 25.0 ± 14.3. At baseline, a history of psychiatric disorder was documented in 214 (43%) patients (depression in 35% of patients, anxiety in 6% and other psychiatric diagnosis in 2.2%). Patients with a history of depression were older (p=0.0021), more likely to report a history of drinking alcohol either at baseline (p=0.0434) or 1-year after surgery (p= 0.0302), and more likely to be female (p=0.0079) and Caucasian (p=0.0096) than patients without psychiatric history. The depression cohort of this study also had significantly higher triglyceride levels (p= 0.0492) than any other psychiatric diagnosis cohort, and the highest rates of hyperlipidemia (p = 0.012) and hypertension diagnoses (p = 0.0074) out of all cohorts, including the cohort of subjects never diagnosed with a psychiatric disorder. Conclusions: Patients undergoing weight reduction surgery seem to have high prevalence of depression and anxiety. Patients previously diagnosed with depression also appear to have a significantly higher rate of hypertension and hyperlipidemia than patients who were never diagnosed with a psychiatric disorder.
机译：背景：肥胖可能与精神疾病如抑郁症有关。目的：确定体重过重患者的精神疾病患病率和关联。方法：纳入计划进行减肥手术的患者。对于每位患者，均收集了术前的临床和精神病学数据。术后1年可获得随访数据。将患有精神疾病的患者与没有精神疾病的患者进行比较。曼-惠特尼非参数检验用于比较数值参数，而某些临床和人口统计学事件的发生率通过卡方均一性检验验证。结果：499名患者包括：年龄：42.8±11.0岁，男性20％，白种人76％，BMI 46.8±10.8，ALT 32.5±21.7和AST 25.0±14.3。在基线时，有214名患者（43％）记录了精神病史（抑郁症患者占35％，焦虑症患者占6％，其他精神疾病诊断者占2.2％）。有抑郁史的患者年龄较大（p = 0.0021），在基线时（p = 0.0434）或手术后1年（p = 0.0302）更有可能报告饮酒史，而女性更容易（ p = 0.0079）和白种人（p = 0.0096）比没有精神病史的患者高。这项研究的抑郁人群的甘油三酸酯水平也明显高于其他任何精神病学诊断人群，高脂血症发生率（p = 0.012）和高血压诊断率最高（p = 0.0074），其中包括从未诊断出患有精神疾病的受试者队列。结论：进行减重手术的患者似乎患抑郁症和焦虑症的几率很高。与从未被诊断出患有精神疾病的患者相比，先前被诊断出患有抑郁症的患者似乎也具有明显更高的高血压和高脂血症发生率。

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