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首页> 外文期刊>The Open Sports Medicine Journal >Coenzyme Q10 Supplementation Decreases Oxidative Stress and Improves Physical Performance in Young Swimmers: A Pilot Study
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Coenzyme Q10 Supplementation Decreases Oxidative Stress and Improves Physical Performance in Young Swimmers: A Pilot Study

机译：辅酶Q10补充剂可减轻年轻游泳者的氧化应激并改善其身体表现：一项初步研究

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Background: The purpose of this study was to evaluate the effects of short term (12 day) Coenzyme Q10 (CoQ10) supplementation on blood oxidative stress biomarkers and physical performance in young swimmers. Methods: Sixteen young swimmers (7 males and 9 females, aged 15.13±0.96 years) who were involved in a sport hero project at Chiang Mai province participated as subjects during this 22 day study. Regular training for swimmers was carried out for the first 9 days. Supplementation with 300mg CoQ10 (Soft gel; Swanson Ultra, USA) was then administered daily for 12 days. Blood samples were collected in EDTA-anticoagulant tubes before (days 1 and 9 of the control period) and after the 12 day supplementation period (day 22). Plasma was separated and used for the determination of malondialdehyde (MDA), nitric oxide (NOx), protein hydroperoxide (PrOOH), total antioxidant capacity (TAC), and CoQ10; whereas reduced glutathione (GSH) was measured in erythrocytes. Exhaustive exercise time was evaluated before (days 1 and 9) and after-supplementation (day 22) on a mechanical treadmill using a modified Bruce protocol. Swimming speeds for both 100 and 800 meters were also recorded. Repeated measurement and Bonferroni correction were used for statistical analysis (p = 0.05). Results: Over the course of the 9 day control period before supplementation, all parameters (MDA, NOx, PrOOH, CoQ10, GSH, TAC, treadmill exhaustion time, and swimming time for either 100 or 800 meters) did not differ (p > 0.05). After CoQ10 supplementation, the levels of plasma MDA, NOx, and PrOOH were significantly decreased when compared to the pre-supplement period (p < 0.05). Moreover, plasma CoQ10 (2.34±0.78 μg/ml vs 1.10±0.38 μg/ml) and erythrocyte GSH (14.51±1.99 vs 8.90±1.84 μmol/g Hb) significantly increased (p < 0.05). Maximal treadmill time was increased significantly (22.92±4.89 mins) when compared to pre-CoQ10 supplementation (p < 0.05), whereas, the swimming time improved significantly for 100 meters when compared to pre-supplementation (p < 0.05), with no difference in swim time recorded for 800 meters (p > 0.05). Conclusion: Twelve days of CoQ10 supplementation reduces oxidative stress, improves running time until exhaustion, as well as short distance swim sprint time, within a sample of young swimmers.
机译：背景：本研究的目的是评估短期（12天）辅酶Q10（CoQ10）补充对年轻游泳者血液氧化应激生物标志物和身体机能的影响。方法：在这个为期22天的研究中，参加了清迈省体育英雄项目的16名年轻游泳者（男7例，女9例，年龄15.13±0.96岁）作为研究对象。在开始的前9天对游泳者进行了定期培训。然后每天补充300mg CoQ10（软凝胶; Swanson Ultra，美国），持续12天。在补血的第12天（第22天）之前（对照组的第1天和第9天）和EDTA抗凝管中采集血液样本。分离血浆并用于测定丙二醛（MDA），一氧化氮（NOx），蛋白质氢过氧化物（PrOOH），总抗氧化剂容量（TAC）和CoQ10;而减少的谷胱甘肽（GSH）在红细胞中测量。在机械跑步机上使用改良的Bruce规程评估了运动前（第1天和第9天）和补充运动后（第22天）的运动时间。还记录了100米和800米的游泳速度。重复测量和Bonferroni校正用于统计学分析（p = 0.05）。结果：在补充前的9天控制期内，所有参数（MDA，NOx，PrOOH，CoQ10，GSH，TAC，跑步机的用力时间以及100或800米的游泳时间）均没有差异（p> 0.05） ）。补充辅酶Q10后，血浆MDA，NOx和PrOOH的水平与补充前的时期相比显着降低（p <0.05）。此外，血浆辅酶Q10（2.34±0.78μg/ ml对1.10±0.38μg/ ml）和红细胞GSH（14.51±1.99对8.90±1.84μmol/ g Hb）显着增加（p <0.05）。与补充CoQ10之前相比，最大跑步机时间显着增加（22.92±4.89分钟）（p <0.05），而与补充前相比，最长跑步时间达到100米（p <0.05），无差异记录的游泳时间为800米（p> 0.05）。结论：在年轻游泳者的样本中，补充CoQ10的12天可减少氧化应激，延长直至疲惫的跑步时间，以及短距离游泳冲刺时间。

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