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首页> 外文期刊>The Open Pediatric Medicine Journal >Diagnostic Markers for Identifying Sepsis in Patients with SystemicInflammatory Response Syndrome (SIRS): A Prospective Study
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Diagnostic Markers for Identifying Sepsis in Patients with SystemicInflammatory Response Syndrome (SIRS): A Prospective Study

机译：诊断系统性炎症反应综合征（SIRS）败血症的诊断标记物：一项前瞻性研究

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Sepsis caused by infection remains a major cause of mortality and morbidity among children. Several inflammatory markers have failed to meet the requirements for early diagnosis of sepsis. We saw the potential value of measuring the total leukocyte count and the inflammatory markers C reactive protein (CRP), procalcitonin (PCT) and interleukin (IL) 6 in patients with SIRS for early identifying of sepsis. Children with SIRS (n = 52) were included in a prospective study. Changes in the total leukocyte count and levels of inflammatory markers and their inter-correlations were evaluated in SIRS and sepsis patients at different time points. Sepsis was recognized in 21% of the SIRS patients. There was a statistically significant difference between PCT and CRP levels in the SIRS and sepsis patient groups. In patients with sepsis, the IL6 level at the outset of the study had a mean value of 476.68 ± 955.137 pg/ml, which differed significantly from the mean IL6 level in SIRS patients (51.3 ± 137.5 pg/ml). The IL6 level in sepsis patients decreased significantly after 24 hours. We conclude that SIRS and sepsis patients differed significantly in respect of changes in CRP, PCT and IL6 levels. In view of the relatively small number of subjects in the sepsis group we can only suggest that special attention should be paid to SIRS patients with elevated levels of those indicators. A continuing search for specific and sensitive inflammatory markers and their combinations in SIRS patients is required so that sepsis can be diagnosed early enough.
机译：感染引起的败血症仍然是儿童死亡和发病的主要原因。几种炎症标记物未能满足脓毒症早期诊断的要求。我们看到了在SIRS患者中测量白细胞总数和炎性标志物C反应蛋白（CRP），降钙素原（PCT）和白介素（IL）6的潜在价值，可早期识别败血症。 SIRS儿童（n = 52）被纳入一项前瞻性研究。在不同的时间点对SIRS和败血症患者评估总白细胞计数和炎症标志物水平的变化及其相互关系。在21％的SIRS患者中认识到败血症。 SIRS和败血症患者组的PCT和CRP水平之间存在统计学上的显着差异。在败血症患者中，研究开始时的IL6水平平均值为476.68±955.137 pg / ml，与SIRS患者的平均IL6水平显着不同（51.3±137.5 pg / ml）。脓毒症患者的IL6水平在24小时后显着下降。我们得出结论，SIRS和败血症患者在CRP，PCT和IL6水平的变化方面存在显着差异。鉴于脓毒症组的受试者相对较少，我们只能建议应该特别注意那些指标升高的SIRS患者。需要对SIRS患者中的特异性和敏感性炎症标志物及其组合进行持续搜索，以便可以及早诊断败血症。

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