Reversion to the Neurovilurent Genome Sequence of Polio Vaccine VirusIsolated from Community-Acquired Meningitis

Zenichiro Kato; Yasushi Shimada; Hiroaki Ishiko; Naomi Kondo

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Reversion to the Neurovilurent Genome Sequence of Polio Vaccine VirusIsolated from Community-Acquired Meningitis

机译：从社区获得性脑膜炎分离到脊髓灰质炎疫苗病毒的神经衰弱基因组序列。

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Neurologic complication associated with the use of live attenuated oral poliomyelitis vaccine is uncommon, but vaccine-associated paralytic poliomyelitis in recipients or contacts has sometimes been reported. We report here a community- acquired aseptic meningitis case and the genetic investigation of the isolated poliovirus type 2. The results of the genetic analysis indicate that the mechanism of this meningitis could be the result of the reversion of the virus during replication in the other vaccine recipients, suggesting a quest for revising the current vaccination program.

机译：与口服减毒活脊髓灰质炎疫苗的使用相关的神经系统并发症并不常见，但有时已报道了受者或接触者与疫苗相关的麻痹性脊髓灰质炎。我们在这里报告了一个社区获得性无菌性脑膜炎病例和分离的2型脊髓灰质炎病毒的基因研究。遗传分析的结果表明，这种脑膜炎的机制可能是另一种疫苗在复制过程中病毒逆转的结果接受者，建议寻求修订当前的疫苗接种计划。

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《The Open Pediatric Medicine Journal》 |2009年第1期|共2页
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Zenichiro Kato; Yasushi Shimada; Hiroaki Ishiko; Naomi Kondo;
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1. Shedding and Reversion of Oral Polio Vaccine Type 3 in Mexican Vaccinees: Comparison of Mutant Analysis by PCR and Enzyme Cleavage to a Real-Time PCR Assay [J] . Devasena Gnanashanmugam, Meira S. Falkovitz-Halpern, Anthony Dodge, Journal of Clinical Microbiology . 2007,第8期

机译：墨西哥疫苗中3型口服脊髓灰质炎疫苗的脱落和逆转：通过PCR和酶切与实时PCR分析进行突变分析的比较
2. Mutation, Selection, and Bottlenecks in Polio Vaccine Reversion [J] . Ebel Gregory D. Cell Host & Microbe . 2021,第1期

机译：脊髓灰质炎疫苗逆转中的突变，选择和瓶颈
3. Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence [J] . Yeh Ming Te, Bujaki Erika, Dolan Patrick T., Cell Host & Microbe . 2020,第5期

机译：工程活衰减的脊髓灰质炎疫苗，以防止逆转毒力
4. Single Injection Delivery System for Sabin Inactivated Polio Vaccine [C] . Xueguang Lu, Kevin J. McHugh, Zachary Tochka, Society for Biomaterials annual meeting and exposition . 2019

机译：萨宾灭活脊髓灰质炎疫苗单次注射输送系统
5. Bioinformatic analysis of viral genomic sequences and concepts of genome-specific rational vaccine design. [D] . Chatterjee, Sharmistha P. 2013

机译：病毒基因组序列的生物信息学分析和基因组特异性合理疫苗设计的概念。
6. Shedding and Reversion of Oral Polio Vaccine Type 3 in Mexican Vaccinees: Comparison of Mutant Analysis by PCR and Enzyme Cleavage to a Real-Time PCR Assay [O] . Devasena Gnanashanmugam, Meira S. Falkovitz-Halpern, Anthony Dodge, 2007

机译：墨西哥疫苗中3型口服脊髓灰质炎疫苗的脱落和逆转：通过PCR和酶切与实时PCR分析进行突变分析的比较
7. Reversion to the Neurovilurent Genome Sequence of Polio Vaccine Virus Isolated from Community-Acquired Meningitis [O] . Zenichiro Kato, Yasushi Shimada, Hiroaki Ishiko, 2009

机译：从社区获得的脑膜炎中分离的脊髓灰质炎疫苗病毒的神经潜水喂养基因组序列恢复

Reversion to the Neurovilurent Genome Sequence of Polio Vaccine VirusIsolated from Community-Acquired Meningitis

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