• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Open Pediatric Medicine Journal >Temporal Variation of Ljungan Virus Antibody Levels in Relation to IsletAutoantibodies and Possible Correlation to Childhood Type 1 Diabetes
【24h】

Temporal Variation of Ljungan Virus Antibody Levels in Relation to IsletAutoantibodies and Possible Correlation to Childhood Type 1 Diabetes

机译：Ljungan病毒抗体水平与胰岛自身抗体的时间变化及其与儿童1型糖尿病的可能相关性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Viral infection may trigger islet autoimmunity, type 1diabetes (T1D), or both. Fluctuating population density of bank voles as a putative reservoir of Ljungan virus has been claimed to be associated with variations in T1D incidence rate (IR). We tested the hypothesis that Ljungan virus antibodies reflecting prior exposure(s) to the virus may be associated with islet autoimmunity, childhood diabetes or both. Incident, 0-18y, T1D patients (n = 63) were studied along with age and sample time matched controls (n = 126). The younger children (< 9 years) tended to have a higher incidence rate during winter (IR = 67.6, 95%CI 41.9-103.5) compared to summer (IR = 33.6, 95%CI 15.3-63.9) months. The proportion of children with high level antibodies against Ljungan virus (LVAb) were both younger compared to the rest of the children (p < 0.002) and correlated with half yearly T1D IR (r = 0.78, p = 0.005). High level LVAb fluctuating with season and correlating with T1D IR indicates that past exposure to Ljungan virus may be associated with T1D.
机译：病毒感染可能会触发胰岛自身免疫，1型糖尿病（T1D）或两者兼有。据称作为Ljungan病毒的潜在库的岸田鼠种群密度的波动与T1D发生率（IR）的变化有关。我们检验了假说，反映先前接触该病毒的Ljungan病毒抗体可能与胰岛自身免疫性疾病，儿童糖尿病或两者都有关系。研究对象是0-18岁的T1D患者（n = 63），以及年龄和样本时间相符的对照组（n = 126）。与夏季（IR = 33.6，95％CI 15.3-63.9）相比，冬季（<9岁）的幼儿（IR = 67.6，95％CI 41.9-103.5）发病率更高。与其他儿童相比，具有抗Ljungan病毒（LVAb）高水平抗体的儿童比例既年轻（p <0.002），又与半年半年的T1D IR相关（r = 0.78，p = 0.005）。高水平的LVAb随季节波动并与T1D IR相关，这表明过去接触Ljungan病毒可能与T1D相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号