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首页> 外文期刊>The Open Pediatric Medicine Journal >Tobacco Smoke Exposure and Somatic Mutation in Newborns
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Tobacco Smoke Exposure and Somatic Mutation in Newborns

机译：新生儿烟草烟雾暴露与体细胞突变

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Maternal exposure to tobacco smoke is known to have deleterious effects on the developing fetus, but it has only recently been shown that there may be life-long consequences due to genotoxic damage. Analysis of newborn cord bloods with the GPA somatic mutation assay demonstrates a significant effect of maternal active smoking and suggests that similar mutational induction occurs in mothers who experience only secondary exposure to environmental tobacco smoke (ETS). Moreover, in both cases, mutational induction occurs by the same molecular mechanism, likely chromosome missegregation, resulting in an effective loss of one parental chromosome 4 and duplication of the other. These data also suggest that quitting smoking during pregnancy without actively avoiding secondary ETS exposure is not effective at protecting the unborn child from the genotoxic effects of tobacco smoke.
机译：已知孕妇暴露于烟草烟雾对发育中的胎儿具有有害作用，但直到最近才表明，由于遗传毒性损害，可能会终身终身。用GPA体细胞突变检测法对新生儿脐带血进行的分析表明，母亲主动吸烟具有显着效果，并表明类似的突变诱导发生在仅二次暴露于环境烟草烟雾（ETS）的母亲中。而且，在两种情况下，突变诱导都是通过相同的分子机制发生的，可能是染色体错聚，导致一个亲本染色体4的有效丢失而另一个亲本染色体4的重复。这些数据还表明，在怀孕期间戒烟而不积极避免二次ETS暴露不能有效地保护未出生的孩子免受烟草烟雾的遗传毒性影响。

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