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首页> 外文期刊>Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects >The effects of maternal cigarette smoke exposure on somatic mutant frequencies at the hprt locus in healthy newborns.
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The effects of maternal cigarette smoke exposure on somatic mutant frequencies at the hprt locus in healthy newborns.

机译：孕妇吸烟对健康新生儿hprt位点体细胞突变频率的影响。

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摘要

We utilized the hprt T-cell cloning assay to prospectively determined the somatic mutant frequency at the hprt locus of fetal T-lymphocytes exposed in utero to maternal active and passive cigarette smoke. In addition, a maternal questionnaire was administered to evaluate a number of social and medical parameters that may effect hprt mutant frequency. Newborn cord blood plasma cotinine levels were determined on all subjects to compare in utero tobacco metabolite levels with maternal smoking histories. A total of 63 newborns were enrolled and placed into four groups: Group I (n = 21), newborns whose mothers had no history of active or passive cigarette exposure during the pregnancy; Group II (n = 12), newborns whose mothers actively smoked cigarettes throughout the pregnancy; Group III (n = 8), newborns whose mothers actively smoked cigarettes during first trimester only; and Group IV (n = 22), newborns whose mothers were exposed only to passive cigarette smoke. Our analysis showed no statistically significant difference in hprt mutation frequency between any of the four groups. A significant increase in plasma cord blood cotinine was detected in Group II, newborns whose mothers were active cigarette smokers throughout the pregnancy. Our data indicate that exposure to active and passive maternal cigarette smoke in utero does not result in a significant increase in somatic mutant frequency as determined by the hprt T-cell cloning assay.
机译：我们利用hprt T细胞克隆测定法前瞻性地确定了子宫内暴露于母体主动和被动吸烟的胎儿T淋巴细胞hprt基因座的体细胞突变频率。此外，还进行了产妇问卷调查，以评估可能影响hprt突变体频率的许多社会和医学参数。确定所有受试者的新生儿血浆血浆可替宁水平，以比较宫内烟草代谢产物水平与孕妇吸烟史。共有63名新生儿入组，分为四组：第I组（n = 21），其母亲在怀孕期间没有主动或被动吸烟的病史;第二组（n = 12），其母亲在整个怀孕期间积极吸烟的新生儿;第三组（n = 8），其母亲仅在孕早期积极吸烟的新生儿; IV组（n = 22），其母亲仅暴露于被动香烟烟雾的新生儿。我们的分析显示，四组中任何一组的hprt突变频率均无统计学上的显着差异。在第二组中检测到血浆脐带血可替宁的显着增加，这些新生儿的母亲在整个怀孕期间都是活跃的吸烟者。我们的数据表明，通过hprt T细胞克隆试验确定，子宫内暴露于主动和被动孕妇香烟不会导致体细胞突变体频率显着增加。

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