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Tobacco Smoking Can Potentiate C-fiber Evoked Potentials in Human Brain

机译:吸烟可以增强人脑中C纤维诱发的电位

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The effects of smoking and nicotine on ultralate laser evoked potentials (LEPs), the EEG responses to C-fiber stimulation by a laser beam, were investigated in humans. Ultralate LEPs were repeatedly measured in two sessions, one after smoking, and the other in abstinence from smoking. The dominant frequency of the background EEG alpha activity, heart rate and venous plasma nicotine concentration were also measured. The peak-to-peak amplitude of the two major components (N2 and P2) of ultralate LEPs was significantly correlated both with the plasma nicotine concentration and with the background alpha frequency. The results suggest an arousal effect of nicotine on C-fiber mediated pain. The effect of nicotine on C-fiber LEPs was in the opposite direction of that on Aδ fiber LEPs. The difference between C and Aδ fibers might indicate a difference in effects of nicotine on first and second pain responses.
机译:在人类中研究了吸烟和尼古丁对超激光激发电位(LEPs),EEG对激光对C纤维刺激的反应的影响。在两个疗程中重复测量了超微结构的LEP,一次是在吸烟后,另一次是在戒烟中。还测量了背景脑电图α活动,心率和静脉血浆尼古丁浓度的主要频率。超微粒子LEP的两个主要成分(N2和P2)的峰峰幅度与血浆烟碱浓度和背景α频率均显着相关。结果表明尼古丁对C纤维介导的疼痛有唤醒作用。尼古丁对C纤维LEP的作用与Aδ纤维LEP的作用相反。 C和Aδ纤维之间的差异可能表明尼古丁对第一和第二种疼痛反应的影响有所不同。

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