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首页> 外文期刊>The Open Physiology Journal >Grape Seed Procyanidins Improve Diabetic Symptoms in Mice with Streptozotocin-Induced Diabetes
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Grape Seed Procyanidins Improve Diabetic Symptoms in Mice with Streptozotocin-Induced Diabetes

机译：葡萄籽原花青素可改善链脲佐菌素诱发的糖尿病小鼠的糖尿病症状。

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Grape seed procyanidins (GSPCs) are bioflavonoid polymers that have been shown to have health benefits. Weassessed the antidiabetic effect of GSPC in mice. Mice with streptozotocin(STZ)-induced diabetes were orally or intraperitoneallyadministered saline or 40-100 mg GSPC/kg BW daily for 7-10 d. We monitored body weight, blood glucoselevels, amounts of food and water consumed, and amounts of urine and feces excreted. On the final day, we analyzedplasma chemistry and found that GSPC, but not structurally related monomers (e.g., catechin and epicatechin), reducedthe glucose levels, food and water intake, and urine and feces excreted, all of which had increased due to STZ administration.This suggests a procyanidin-dependent effect of grape seed polyphenols on diabetes. Oral administration of GSPCwas less effective within 9 d than was intraperitoneal administration of GSPC, suggesting that the effect is routedependent.The decrease in diabetic blood glucose levels was reversible; when GSPC administration was stopped, glucoselevels rose. However, although pretreatment with GSPC for 7 d did not completely prevent STZ-induced diabetic effects,it rapidly reduced them. Treatment with GSPC reduced fasting glucose levels and improved glucose tolerance in STZtreatedmice, in addition to decreasing STZ-stimulated levels of plasma triglyceride and cholesterol, creatinine, uric acid,and alkaline phosphatase activity. Moreover, GSPC suppressed the reduction in pancreatic islets and the decrease inplasma insulin hormone levels caused by STZ. Our findings indicate that GSPC improves hyperglycemia, polydipsia,polyuria, and polyphagia in mice with STZ-induced diabetes.
机译：葡萄籽原花青素（GSPC）是生物类黄酮聚合物，已显示对健康有益。我们评估了GSPC对小鼠的抗糖尿病作用。链脲佐菌素（STZ）诱导的糖尿病小鼠每天口服或腹腔注射生理盐水或40-100 mg GSPC / kg BW，持续7-10 d。我们监测了体重，血糖水平，食物和水的消耗量以及尿液和粪便的排泄量。在最后一天，我们分析了血浆化学成分，发现GSPC而不是与结构相关的单体（例如儿茶素和表儿茶素）降低了葡萄糖含量，食物和水的摄入量以及尿液和粪便的排泄，所有这些都由于服用STZ而增加这表明葡萄籽多酚对糖尿病具有前花青素依赖性作用。口服GSPC在9 d内效果不如腹膜内GSPC，这表明该效果是路径依赖的。糖尿病血糖水平的降低是可逆的。停止GSPC给药后，葡萄糖水平上升。然而，尽管用GSPC预处理7 d不能完全预防STZ诱导的糖尿病作用，但可以迅速减轻它们。 GSPC处理不仅降低了STZ刺激的血浆甘油三酸酯和胆固醇，肌酐，尿酸和碱性磷酸酶活性，还降低了STZ治疗的小鼠的空腹血糖水平并改善了葡萄糖耐量。此外，GSPC抑制了由STZ引起的胰岛减少和血浆胰岛素激素水平的降低。我们的发现表明，GSPC可改善STZ诱导的糖尿病小鼠的高血糖，多尿，多尿和多食。

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