...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Thoracic cancer. >Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature
【24h】

Primary extranodal natural killer/T‐cell lymphoma of bronchus and lung: A case report and review of literature

机译：支气管和肺原发性结外自然杀伤/ T细胞淋巴瘤：一例病例报告并文献复习

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AbstractPrimary pulmonary non-Hodgkin's lymphoma (NHL) is very rare. It represents less than 1% of all NHL, and 0.5–1% of all primary pulmonary malignancies. Almost all cases of primary pulmonary NHL originate from B-cell lineage. We present a case of a 53-year-old man with primary extranodal NK/T-cell lymphoma of the bronchus and lung, presented progressive dyspnea caused by right lower lung consolidation, and pleural effusion. Initial chest computed tomography suggested advanced lung cancer. Bronchofiberscopy showed a polypoid tumor on which a biopsy was performed. Histologically, the diffusely infiltrative atypical cells were positive for cytoplasmic CD3, CD56, granzyme B, and negative for cytokeratin, CD20 immunostains, suggesting NK/T cell lineages. In situ hybridization for Epstein-Barr virus encoded ribonucleic acid (EBER) was positive. Herein, we discuss the clinicopathological features of this case and review the literature on primary extranodal NK/T-cell lymphoma of the lung. Compared with other patients, who died after the first cycle of chemotherapy and/or within three months, our patient had longer survival under aggressive chemotherapy and auto-peripheral blood stem cell transplantation.
机译：摘要原发性肺非霍奇金淋巴瘤（NHL）非常罕见。它仅占所有NHL的不到1％，和所有原发性肺部恶性肿瘤的0.5–1％。几乎所有原发性肺NHL病例均来自B细胞谱系。本例为一例53岁男性支气管和肺原发性结外NK / T细胞淋巴瘤，表现为由右下肺巩固和胸腔积液引起的进行性呼吸困难。最初的胸部计算机断层扫描提示晚期肺癌。纤维支气管镜检查显示息肉样肿瘤。从组织学上看，弥漫性浸润性非典型细胞的胞质CD3，CD56，颗粒酶B呈阳性，而细胞角蛋白，CD20免疫染色呈阴性，提示NK / T细胞谱系。 Epstein-Barr病毒编码的核糖核酸（EBER）的原位杂交呈阳性。在此，我们讨论该病例的临床病理特征，并回顾有关原发性肺外结节NK / T细胞淋巴瘤的文献。与其他患者相比，在第一轮化疗后和/或三个月内死亡的患者，在积极化疗和自体外周血干细胞移植后，该患者的生存期更长。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号