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首页> 外文期刊>Thoracic cancer. >Diagnosis of the invasiveness of lung adenocarcinoma manifesting as ground glass opacities on high‐resolution computed tomography
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Diagnosis of the invasiveness of lung adenocarcinoma manifesting as ground glass opacities on high‐resolution computed tomography

机译：在高分辨率计算机断层扫描上诊断为玻璃膜混浊的肺腺癌的浸润性

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AbstractBackgroundTo explore the diagnostic method in assessing the malignancy of pulmonary adenocarcinoma characterized by ground glass opacities (GGO) on computed tomography (CT).MethodsPreoperative CT data for preinvasive and invasive lung adenocarcinomas were analyzed retrospectively. GGO lesions that were detected on lung windows but absent using the mediastinal window were subject to adjustment of the window width, which was reduced with the fixed interval of 100 HU until the lesions were no longer evident, with a fixed mediastinal window level of 40 HU. The shape, smoking habits, size of the lesion on the lung window, and window width at which lesions disappeared were compared and receiver operating characteristic curves were used to determine the optimal cut-off of the lesion size and window width to differentiate between these invasive and preinvasive lesions.ResultsOf the 209 lung adenocarcinomas, 102 were preinvasive (25 atypical adenomatous hyperplasia and 77 adenocarcinoma in situ), while 107 were invasive (78 minimally invasive adenocarcinoma and 29 invasive adenocarcinoma). The shape, lesion size, and window width at which lesions were no longer evident differed significantly between the two groups (P 0.05). The size of 8.9 mm and a window width of 1250 HU were the optimal cut-off to differentiate between preinvasive and invasive lesions.ConclusionThe shape, size of the lesion, and window width on high-resolution CT may be useful in assessing the invasiveness of lung adenocarcinoma that manifests as GGO. Irregular lesions that disappear at window width 1250 HU, with a diameter of 8.9 mm are more likely to be invasive.
机译：摘要背景探讨在计算机断层扫描（CT）上评估以玻璃液混浊（GGO）为特征的肺腺癌恶性程度的诊断方法。方法回顾性分析术前和浸润性肺腺癌的术前CT数据。在肺窗上检测到但在纵隔窗上不存在的GGO病变需调整窗宽，以固定的100 HU间隔减小，直到病变不再明显为止，以固定的纵隔窗水平40 HU减少。比较肺窗上病变的形状，吸烟习惯，病变大小和病变消失时的窗宽，并使用接收器操作特征曲线确定病变大小和窗宽的最佳临界值，以区分这些侵入性结果在209例肺腺癌中，有102例为浸润前（25例非典型腺瘤增生和77例原位腺癌），而107例为浸润性（78例微浸润性腺癌和29例浸润性腺癌）。两组之间病变不再明显的形状，病变大小和窗口宽度显着不同（P <0.05）。 8.9mm的大小和1250 HU的窗口宽度是区分浸润前病变和浸润性病变的最佳切入点。结论高分辨率CT上病变的形状，大小和窗口宽度可能有助于评估食管癌的浸润性。表现为GGO的肺腺癌。在窗口宽度<1250 HU处消失且直径> 8.9mm的不规则病变更有可能是浸润性的。

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