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首页> 外文期刊>The Professional Medical Journal >PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A TERTIARY CARE HOSPITAL.
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PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A TERTIARY CARE HOSPITAL.

机译：三级耐药医院中耐甲氧西林金黄色葡萄球菌的流行及其耐药性研究。

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Introduction: The versatility of Staphylococcus aureus has been transformedas “Methicillin resistant Staphylococcus aureus”. The most challenging are the disastrousvirulence patterns being expressed due to the selection pressure of antibiotics. For assessingthe prevalence of methicillin resistant Staphylococcus aureus; screening by cefoxitin disc (30μg)diffusion method is still a realistic approach among conventional phenotypic methods, beingapplied in most of the laboratories. This reliable and feasible technique contributes significantlyfor MRSA detection. Objective: To evaluate the prevalence and identify the sensitivity pattern ofmethicillin resistant Staphylococcus aureus isolates from different clinical specimens in a tertiarycare hospital. Study Design: Descriptive study. Setting: Pathology Department, MicrobiologyLaboratory, PGMI. Period: January 2015 to December 2015. Materials & Methods: A total 713clinical isolates of Staphylococcus aureus were processed. Identification and confirmation ofStaphylococcus aureus was done by colony morphology on blood agar, gram stain, catalase,coagulase and DNA-ase tests. Screening for methicillin resistance was done using cefoxitindisc (30μg, OXOID); while different antibiotic discs were used to assess the sensitivity profileby Modified Kirby-Bauer Disc Diffusion method according to CLSI guidelines (2016). Results:Out of 713 Staphylococcus aureus isolates, 92 (12.90%) isolates were labelled as methicillinresistant by cefoxitin disc diffusion test. Out of 92 MRSA isolates, 57 (14.65%) were recoveredfrom male patients and 35 (10.80%) from female patients. While, 60 (65.22%) MRSA isolatesshowed hemolysis on blood agar. Among 92 MRSA isolates, 41 (44.57%) were recoveredfrom pus specimen. Resistance to trimethoprim/sulfamethoxazole was highest (65.22%) afterpenicillin (100%); while all the MRSA isolates were 100% sensitive to both vancomycin andlinezolid. Conclusion: The prevalence of MRSA in hospital care settings is of great clinicalconcern. To combat this public health threat effectively, continuous surveillance of healthcareassociated infections, along with local antibiotic sensitivity pattern of MRSA; as well asformulation of a definite antibiotic policy is required.
机译：简介：金黄色葡萄球菌的多功能性已转变为“耐甲氧西林的金黄色葡萄球菌”。最具挑战性的是由于抗生素的选择压力而导致的灾难性毒力模式。用于评估耐甲氧西林的金黄色葡萄球菌的患病率;在大多数表型实验室中，头孢西丁圆盘（30μg）扩散法进行筛查仍是常规表型方法中的一种实际方法。这种可靠且可行的技术为MRSA检测做出了重要贡献。目的：评估三级医院中不同临床标本对耐甲氧西林金黄色葡萄球菌分离株的患病率并确定其敏感性模式。研究设计：描述性研究。地点：PGMI微生物实验室病理科。时间：2015年1月至2015年12月。材料与方法：共处理了713株金黄色葡萄球菌临床分离株。金黄色葡萄球菌的鉴定和确认是通过对血琼脂，革兰氏染色，过氧化氢酶，凝固酶和DNA酶测试进行菌落形态学来进行的。使用头孢西丁碟（30μg，OXOID）筛选耐甲氧西林;而根据CLSI指南（2016），采用改良的Kirby-Bauer椎间盘扩散法通过不同的抗生素椎间盘评估敏感性分布。结果：在头孢西丁碟片扩散试验中，在713株金黄色葡萄球菌分离物中，有92株（占12.90％）被标记为耐甲氧西林。在92份MRSA分离物中，男性患者中回收了57（14.65％），女性患者中回收了35（10.80％）。同时，有60（65.22％）个MRSA分离物在血琼脂​​上显示溶血。在92份MRSA分离物中，从脓液标本中回收了41份（44.57％）。青霉素（100％）后对甲氧苄啶/磺胺甲恶唑的耐药性最高（65.22％）;而所有MRSA分离株对万古霉素和利奈唑胺均100％敏感。结论：MRSA在医院护理中的流行具有重大的临床意义。为了有效应对这一公共卫生威胁，对医疗保健相关感染以及MRSA的局部抗生素敏感性模式进行持续监测;还需要制定明确的抗生素政策。

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