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首页> 外文期刊>The Open Bioactive Compounds Journal >Insight into Erythrina Lectins: Properties, Structure and Proposed Physiological Significance
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Insight into Erythrina Lectins: Properties, Structure and Proposed Physiological Significance

机译：刺桐凝集素的见解：性质，结构和拟议的生理意义

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The genus Erythrina, collectively known as “coral tree”, are pantropical plants, comprising of more than 112 species. Since the early 1980s, seven of these have been found to possess hemagglutinating activity, although not yet characterized. However, around two dozen galactose-binding lectins have been isolated and fully characterized with respect to their sugar specificity, glycoconjugates agglutination, dependence of activity on metal ions, primary and secondary structures and stability. Three lectins have been fully sequenced and the crystal structures of the two proteins have been solved with and without the haptenic sugar. Lectins isolation and characterization from most of these species usually originated from the seeds, although the proteins from other vegetative tissues have also been reported. The main objective of this review is to summarize the physicochemical and biological properties of the reported purified Erythrina lectins to date. Structural comparisons, based on available lectins sequences, are also made to relate the intrinsic physical and chemical properties of these proteins. Particular attention is also given to the proposed biological significance of the lectins from the genus Erythrina.
机译：刺桐属（Erythrina）被统称为“珊瑚树”，是泛热带植物，由112多个物种组成。自1980年代初以来，尽管尚未鉴定出其中7种具有血凝活性。然而，已分离出大约十二种半乳糖结合凝集素，并就其糖特异性，糖缀合物凝集，活性对金属离子的依赖性，一级和二级结构以及稳定性进行了全面表征。已经对三种凝集素进行了完全测序，并且在有或没有半抗原糖的情况下，已经解析了这两种蛋白质的晶体结构。从大多数这些物种中分离并鉴定出的凝集素通常来自种子，尽管也已报道了来自其他营养组织的蛋白质。这篇综述的主要目的是总结迄今为止报道的纯化的刺桐凝集素的物理化学和生物学特性。还基于可用的凝集素序列进行结构比较，以关联这些蛋白质的内在物理和化学性质。还特别注意拟赤藓菌属植物凝集素的拟议生物学意义。

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