...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Saudi Dental Journal >Evaluation of bone regenerative capacity in rats claverial bone defect using platelet rich fibrin with and without beta tri calcium phosphate bone graft material
【24h】

Evaluation of bone regenerative capacity in rats claverial bone defect using platelet rich fibrin with and without beta tri calcium phosphate bone graft material

机译：富血小板纤维蛋白联合和不联合β三磷酸钙骨移植材料评估大鼠锁骨缺损的骨再生能力

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim To compare bone regeneration in noncritical rat calvarial bone defects filled with platelet-rich fibrin (PRF), alone or combined with beta-tricalcium phosphate (β-TCP), using micro-computed tomographic (MCT) evaluation. Animals and methods Two calvarial bone defects were created in each of 45 male Sprague–Dawley rats (age: 20–22 weeks, weight: 350–450 g), using a dental trephine with an external diameter of 3 mm. The 90 defects were randomly allocated among three groups, each containing 30 unilateral defects in a total of 30 rats. Defects in the control group were allowed to heal spontaneously. Defects in the PRF group received PRF alone. Defects in the PRF/β-TCP group received PRF mixed with β-TCP in a 50?50 percentage. Nine animals (three per group) were killed after 1, 2, 3, 4, and 6 postoperative weeks, and 18 calvarial defects from each period were analyzed for new bone formation and bone mineral density using MCT. Results were compared by a one-way Analysis of Variance with the POST HOC Least Significant Difference test. Results The volume and mineral density of bone formed in the control group were significantly different from those of the other two groups. Greater bone regeneration was observed in defects receiving PRF with β-TCP compared to defects receiving PRF alone in the first 2 weeks ( P 0.001). However, differences in the volume and density of newly formed bone between the PRF and PRF/β-TCP groups were not significant at 3, 4, and 6 postoperative weeks ( P 0.005). Conclusion The addition of β-TCP to PRF significantly improved bone regeneration in the first 2 weeks after surgery. Although the differences between results with and without the addition of β-TCP to PRF were statistically insignificant from weeks 3 to 6, it was nevertheless apparent that the group receiving the combination showed better results. We suggest a synergistic mechanism for this effect.
机译：目的使用微计算机断层扫描（MCT）评价比较单独或与β-磷酸三钙（β-TCP）混合的富含血小板的纤维蛋白（PRF）填充的非关键大鼠颅骨缺损的骨再生。动物和方法使用外径为3 mm的牙花环，在45只雄性Sprague-Dawley大鼠（年龄：20-22周，体重：350-450 g）中，分别制造了两个颅骨缺损。将90个缺陷随机分配到三组中，每组包含30只单侧缺陷。对照组的缺陷可以自愈。 PRF组的缺陷仅接受PRF。 PRF /β-TCP组的缺陷接受了以50％至50％的比例混合了PRF和β-TCP的缺陷。在术后1、2、3、4和6周后杀死9只动物（每组3只），并使用MCT分析每个时期的18个颅骨缺损的新骨形成和骨矿物质密度。将结果通过POST HOC最小显着差异检验进行单向方差分析。结果对照组中形成的骨骼的体积和矿物质密度与其他两组相比有显着差异。与头2周接受单独PRF的缺损相比，接受β-TCP的PRF缺损观察到更大的骨再生（P <0.001）。然而，PRF和PRF /β-TCP组之间新形成的骨的体积和密度差异在术后第3、4和6周没有显着性差异（P> 0.005）。结论PRF中加入β-TCP可以显着改善术后2周内的骨再生。尽管从第3周到​​第6周，在PRF上添加和不添加β-TCP的结果之间的差异在统计学上不显着，但显然接受该组合的组显示出更好的结果。我们建议这种效果的协同机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号